… allograft transplantation. Here, we use a modular system based on a chimeric antigen receptor
(… Thus, transient genetic modification to produce mAbCAR T cells led to durable immune …

… the peripheral blood following transplantation, thus limiting the … receptors or chimeric antigen
receptors (CAR) have been reported by multiple labs since 2005 (7–14). In transplantation, …

… based on antigen-specific Treg therapies in solid organ transplantation were conducted (10, …
most of the patients developed liver transplant tolerance with normal graft function but with …

… with the aim to specifically accumulate at the transplant and induce lasting immune tolerance.
The control participants will undergo kidney transplant as per the planned standard of care …

… tolerance, defined as the absence of a detrimental immune … while maintaining protective
immunity towards pathogens and … transplantation tolerance can occur in liver transplantation …

… Cell therapy with regulatory T cells (Tregs) in solid organ transplantation is a … immunologic
tolerance. Previous clinical studies have demonstrated the safety of Tregs in renal transplant …

… a means to harness the immune system to treat hematologic … rejection and self-tolerance
requires a deep understanding … of a T cell–depleted transplant to induce an immune-mediated …

… role in suppressing immune activation and regulating the host immune response. CAR …
transplant rejection. In the latter, they hold immense potential as mediators of immune tolerance …

… Tregs (arTregs) and chimeric antigen receptor (CAR) Tregs. … to donor antigens and the
reduction in overall body immune … vector of the chimeric antigens from the recipients [113,114]. …

… long-lasting immune tolerance in diabetes and allogeneic skin transplantation models. …
after solid organ transplantation might be a new option to induce tolerance and to minimize …