Comprehensive genomic profiling of small cell lung cancer in Chinese patients and the implications for therapeutic potential

J Hu, Y Wang, Y Zhang, Y Yu, H Chen, K Liu… - Cancer …, 2019 - Wiley Online Library
… In this study, we characterized the genomic alterations profile of Chinese SCLC patients. …
the genomic profile of SCLC in Chinese patients and compare it with Western patients, and …

Comprehensive genomic profiling of lung cancer using a validated panel to explore therapeutic targets in East Asian patients

L Liu, J Liu, DI Shao, Q Deng, H Tang, Z Liu… - Cancer …, 2017 - Wiley Online Library
… for lung cancer in patients of this ethnicity. In this study, we used a well-validated assay to …
comprehensive genomic profiling on tumor specimens from 306 Chinese lung cancer patients

Comprehensive molecular characterization of young Chinese patients with lung adenocarcinoma identified a distinctive genetic profile

H Hou, H Zhu, H Zhao, W Yan, Y Wang, M Jiang… - The …, 2018 - academic.oup.com
… revealed a distinctive genetic profile in younger patients with adenocarcinoma. High frequency
of concurrent EGFR/TP53 mutations was found in the younger patients, which especially …

[HTML][HTML] Utility of comprehensive genomic profiling in directing treatment and improving patient outcomes in advanced non-small cell lung cancer

S Zhao, Z Zhang, J Zhan, X Zhao, X Chen, L Xiao… - BMC medicine, 2021 - Springer
comprehensive genomic profiling in 1564 patients to evaluate the utility of this practice in
treatment selection, trial enrollment, and clinical outcome improvement for Chinese patients

[HTML][HTML] Comprehensive profiling of 1015 patients' exomes reveals genomic-clinical associations in colorectal cancer

Q Zhao, F Wang, YX Chen, S Chen, YC Yao… - Nature …, 2022 - nature.com
The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly
understood due to limited samples or targeted genes in current studies. Here, we perform …

[HTML][HTML] Comprehensive genomic profiling of rare tumors: routes to targeted therapies

S Wang, R Chen, Y Tang, Y Yu, Y Fang… - Frontiers in …, 2020 - frontiersin.org
… even higher in our Chinese rare tumor population. Comprehensive genomic profiling may
offer novel treatment paradigms to address the limited options for patients with rare tumors. …

Comprehensive profiling of BRCA1 and BRCA2 variants in breast and ovarian cancer in Chinese patients

X Gao, X Nan, Y Liu, R Liu, W Zang, G Shan… - Human …, 2020 - Wiley Online Library
… pathogenicity interpretation procedure for Chinese BRCA1/2 variants… the first comprehensive
meta-analysis of Chinese BRCA1/2 … and companion diagnostics in the Chinese population. …

Comprehensive genomic profiling identifies novel genetic predictors of response to anti–PD-(L) 1 therapies in non–small cell lung cancer

W Fang, Y Ma, JC Yin, S Hong, H Zhou, A Wang… - Clinical Cancer …, 2019 - AACR
… In this study, we validated the predictive value of TMB in Chinese patients with NSCLC
following immunotherapy and identified additional biomarkers that might help refine the …

[HTML][HTML] Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib

Y Shang, X Li, W Liu, X Shi, S Yuan, R Huo, G Fang… - Scientific reports, 2020 - nature.com
Chinese patients. In this study, we acquired 371 lung cancer tissue samples from Chinese
patients … University and determined their comprehensive genomic profiles to provide evidence …

[HTML][HTML] Comprehensive genomic profiling of rare tumors in China: routes to immunotherapy

S Wang, Y Fang, N Jiang, S Xing, Q Li, R Chen… - Frontiers in …, 2021 - frontiersin.org
… We look forward to increasing opportunities for Chinese patients with rare tumors to benefit
from targeted therapy and immunotherapy through this world leading research method and …