[HTML][HTML] Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis

JU Igietseme, Y Omosun, O Stuchlik, MS Reed… - PloS one, 2015 - journals.plos.org
… cervical epithelial carcinoma. We tested the hypothesis that Chlamydia induces epithelial-mesenchyme
epithelium; the pathologic process of EMT causes fibrosis and fertility-related …

Molecular pathogenesis of chlamydia disease complications: epithelial-mesenchymal transition and fibrosis

JU Igietseme, Y Omosun, T Nagy, O Stuchlik… - Infection and …, 2018 - Am Soc Microbiol
… the etiology of chlamydia-induced fibrosis. The detailed bioinformatics analyses revealed
that a major category of miRNAs dysregulated by chlamydia during genital chlamydial infection …

[HTML][HTML] A renewed tool kit to explore Chlamydia pathogenesis: from molecular genetics to new infection models

L Dolat, RH Valdivia - F1000Research, 2019 - ncbi.nlm.nih.gov
Chlamydia biovars can induce the transformation of epithelial cells to a more mesenchymal-…
genetics will promote better molecular dissection of Chlamydia pathogenesis in live animals. …

Epidermal Growth Factor Receptor and Transforming Growth Factor β Signaling Pathways Cooperate To Mediate Chlamydia Pathogenesis

JU Igietseme, J Partin, Z George, Y Omosun… - Infection and …, 2020 - Am Soc Microbiol
… induction of pathogenic epithelial-mesenchyme transition (EMT). Chlamydia also upregulates
… and TGF-β signaling pathways cooperate during chlamydial infection for optimal inclusion …

An in vitro human epithelial cell culture system for studying the pathogenesis of Chlamydia trachomatis

PB WYRICK, CH DAVIS, ST KNIGHT… - Sexually transmitted …, 1993 - journals.lww.com
… resulted in a dramatic difference in the number of chlamydial inclusions in susceptible
endometrial epithelial cells. Chlamydial attachment to and infection of estrogen-dominant HEGEC …

[HTML][HTML] The role of infected epithelial cells in Chlamydia-associated fibrosis

LT Caven, RA Carabeo - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
… paradigm of chlamydial pathogenesis, wherein Chlamydia-infected epithelial cells
initiate pro-… Collectively, these reports indicate that Chlamydia induces an epithelial-to-mesenchymal

[HTML][HTML] Chlamydia trachomatis disturbs epithelial tissue homeostasis in fallopian tubes via paracrine Wnt signaling

M Kessler, J Zielecki, O Thieck, HJ Mollenkopf… - The American journal of …, 2012 - Elsevier
mesenchymal transition, a cellular mechanism critical for tissue development and a … the
pathogenic mechanisms of Ctr, we observed a prominent disturbance of epithelial homeostasis …

Is There a Hidden Burden of Disease as a Result of Epigenetic Epithelial-to-Mesenchymal Transition Following Chlamydia trachomatis Genital Tract Infection?

PJ Horner, H Flanagan, AW Horne - The Journal of Infectious …, 2021 - academic.oup.com
… to understand the pathogenesis of CT, suggest that CT can induce the process of
epithelial-to-mesenchymal transition (EMT) through epigenetic changes in the epithelium of the …

[HTML][HTML] … methylation, downregulation of E-cadherin expression, and increased expression of fibronectin and α-SMA—implications for epithelial-mesenchymal …

J Rajić, A Inic-Kanada, E Stein, S Dinić… - Frontiers in cellular …, 2017 - frontiersin.org
Chlamydia trachomatis (Ct) can induce … epithelial-mesenchymal transition (EMT) contributes
to the fibrotic process in trachomatous scarring. Infection of human conjunctival epithelial

Epigenetic changes induced by pathogenic Chlamydia spp

RA Stein, LM Thompson - Pathogens and Disease, 2023 - academic.oup.com
… of pathogenesis, such as the ability of the Chlamydia spp. to induce epithelial-to-mesenchymal
of epigenetic changes to pathogenesis will enhance our knowledge about the biology of …