… 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, more commonly
known as “statins,” are cholesterol-lowering drugs that have been widely used for many years …

… of zinc, a unique characteristic of prostate cells which inhibit m-aconitase, an enzyme for
citrate-… phosphorylation, normal prostate epithelium has higher cholesterol synthesis than other …

… high circulating cholesterol increases risk of aggressive prostate cancer, while cholesterol
… Because statins inhibit an early step in cholesterol synthesis, they also reduce upstream non…

… of cholesterol … cholesterol metabolism as well as by inhibition of other products of the
mevalonate pathway. Intracellular depletion of cholesterol can induce apoptosis through inhibition …

… Accordingly, we found that cholesterol biosynthesis pathway gene set was enriched in high
HMGCR-expressing group, indicating that cholesterol biosynthesis pathway was activated …

… Numerous studies have used a range of statins to show that statin uptake and the inhibition
of cholesterol synthesis are generally higher in the liver compared to other tissues [104], [105]…

… roles of cholesterol accumulation in prostate cancer regulated … cholesterol homeostasis in
prostate cancer is incomplete, as another critical aspect of cholesterol metabolism, cholesterol …

… a tumor-targeted statin to remove sources of cholesterol to the cell and, thus, inhibit de novo
androgen synthesis. One study has explored altering the functionality of the SR-BI in breast …

… Depletion of cholesterol from membrane raft domains not only inhibited … prostate cancer
development and validate cholesterol-lowering drugs as an effective factor in prostate cancer …

… TRAMP, Cox-2 expression increases with progression of carcinogenesis and the use of a
COX-2 inhibitor increases the survival of mice with prostate cancer [87]. Additionally, IL-6, …