… The data presented in this study demonstrate that chondrocyte apoptosis is positively
associated with degree of cartilage matrix damage and that the extent of apoptosis varies with …

… The hypothesis presented here is primarily concerned with the relationship between apoptosis
and cartilage degeneration in osteoarthritis and the signalling pathways and intracellular …

… Secondarily, we aim to explore further the relationship between chondrocyte apoptosis and
the macroscopic/microscopic severity of cartilage damage, and to determine the association …

… In this review, we focused the different kinds of chondrocyte death through a comparison
between data reported in the literature. Chondrocytes … death involved in this degeneration. The …

… cell death is a central feature in OA cartilage degeneration. … uisite for the development of
cartilage degeneration [7]. In … of OA, and the mechanism of chondrocyte death and its regulatory …

… that chondrocyte death may contribute to the pathogenesis of OA. Agerelated changes that
have been observed in human articular cartilage include … to matrix degeneration and eventual …

… These reduce ECM production, disrupt chondrocyte function and damage the structural …
directly or indirectly to chondrocyte death and cartilage degradation by inducing catabolic …

… death appeared in the deep zone as loaded at 7 and 14 MPa but not at 3.5 MPa [29]. Using
repeated loads, chondrocyte death was observed in cartilage … the acute cell death in those …

… chondrocyte death is not a proximate cause of cartilage damage when the death has left the
cartilage … surgery causes chondrocyte death, it is the dysfunction of chondrocytes prior to …

… is crucial in our search for an effective therapeutic agent for this common degenerative
disease. This article will discuss the recent evidence on chondrocyte death in articular cartilage …