WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-κB pathways

EW Bradley, MH Drissi - Molecular endocrinology, 2010 - academic.oup.com
chondrocyte differentiation and further elucidate the effects that Wnt5a has on chondrogenesis
and chondrocyte … represses chondrocyte hypertrophy through novel induction of NF-κB, in …

Activation of NF-κB/p65 facilitates early chondrogenic differentiation during endochondral ossification

MMJ Caron, PJ Emans, DAM Surtel, A Cremers… - PloS one, 2012 - journals.plos.org
… of chondrogenic differentiation is initiated by transient NF-κB/… of chondrogenic differentiation
is regulated by transient NFκB/… differentiation a transient activation of NF-κB/p65 occurs …

Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation

E Olivotto, M Otero, KB Marcu, MB Goldring - RMD open, 2015 - rmdopen.bmj.com
… pathway, has a number of NF-κB-independent and kinase-… chondrocyte hypertrophic
differentiation and collagenase activity. In this short review, we will discuss the role of NF-κB

Redox control of chondrocyte differentiation and chondrogenesis

Y Bai, X Gong, C Dou, Z Cao, S Dong - Free Radical Biology and Medicine, 2019 - Elsevier
… homeostasis of chondrocytes ensures … chondrocyte differentiation. Additionally, the mechanism
by which ROS/RNS regulate signalling proteins and transcription factors in chondrocytes

NF-κB signaling regulates physiological and pathological chondrogenesis

E Jimi, F Huang, C Nakatomi - International journal of molecular sciences, 2019 - mdpi.com
chondrogenic cell line indicate the importance of transient NF-κB activation in the initiation of
chondrogenic differentiation. … activation of NF-κB during the first few hours of chondrogenic

p38/NFkB‐dependent expression of COX‐2 during differentiation and inflammatory response of chondrocytes

V Ulivi, P Giannoni, C Gentili… - Journal of cellular …, 2008 - Wiley Online Library
… the expression of COX-2 in chondrocyte differentiation and inflammatory response we took
advantage of the MC615 chondrogenic cell line able to differentiate in culture, a cell system …

[HTML][HTML] Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells

M Ushita, T Saito, T Ikeda, F Yano… - Osteoarthritis and …, 2009 - Elsevier
chondrogenic differentiation via binding to an NF-κB binding motif in the SOX9 promoter. …
of RelA in chondrogenic differentiation. Among the NF-κB family members transfected in HeLa …

The signaling pathways involved in chondrocyte differentiation and hypertrophic differentiation

J Li, S Dong - Stem cells international, 2016 - Wiley Online Library
… Activation of Wnt signaling promotes osteoblast differentiation but suppresses chondrocyte
differentiation of MSCs [25, 26]. Wnt can be divided into two classes: Wnt-1 class (Wnt-1, -3a, -…

Calcitonin protects chondrocytes from lipopolysaccharide-induced apoptosis and inflammatory response through MAPK/Wnt/NF-κB pathways

LB Zhang, ZT Man, W Li, W Zhang, XQ Wang… - Molecular Immunology, 2017 - Elsevier
… Mitogen-activated protein kinase (MAPK) is a signal transduction pathway in cartilage, which
plays an essential role in chondrogenic differentiation. The MAPK cascade consist of three …

NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism

R Sitcheran, PC Cogswell, AS Baldwin - Genes & development, 2003 - genesdev.cshlp.org
… by or required NF-κB, we performed differentiation experiments in the chondrocytic cell line
NF-κB inhibits mesenchymal chondrocytic differentiation in vivo. MC615 cells expressing Tet…