Interpretation of allele-specific chromatin accessibility using cell state–aware deep learning

ZK Atak, II Taskiran, J Demeulemeester… - Genome …, 2021 - genome.cshlp.org
… Here we generate phased whole genomes with matched chromatin accessibility, histone …
a specialized deep learning model, called DeepMEL2, on melanoma chromatin accessibility

Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification

GE Hoffman, J Bendl, K Girdhar, EE Schadt… - Nucleic acids …, 2019 - academic.oup.com
… These models leverage advances in deep learning (32) to … Here we introduce a deep learning
framework for functional i… epigenetic variation in chromatin accessibility from DNase-seq …

Chromatin accessibility prediction via a hybrid deep convolutional neural network

Q Liu, F Xia, Q Yin, R Jiang - Bioinformatics, 2018 - academic.oup.com
… First, we download Basset, a deep learning … to learn the chromatin accessibility code of
different cell lines but also evaluate genetic variants with potential influence on the accessibility. …

DeepANF: A deep attentive neural framework with distributed representation for chromatin accessibility prediction

Y Guo, D Zhou, R Nie, X Ruan, W Li - Neurocomputing, 2020 - Elsevier
… We develop a hybrid deep learning framework for chromatin accessibility prediction based
… , GRU and attention networks to automatically learn the complex hidden features of DNA …

Chromatin accessibility prediction via convolutional long short-term memory networks with k-mer embedding

X Min, W Zeng, N Chen, T Chen, R Jiang - Bioinformatics, 2017 - academic.oup.com
… Eventually, we hope our deep learning method can allow us achieve excellent performance
in DNA sequence analysis and help boost our understanding of chromatin accessibility

DeepTACT: predicting 3D chromatin contacts via bootstrapping deep learning

W Li, WH Wong, R Jiang - Nucleic acids research, 2019 - academic.oup.com
… However, unless extremely deep sequencing is performed on a … deep learning model, to
integrate genome sequences and chromatin accessibility data for the prediction of chromatin

[PDF][PDF] Incorporating Gene Expression in Genome-wide Prediction of Chromatin Accessibility via Deep Learning

Q Liu, WH Wong, R Jiang - liuqiao.me
chromatin accessibility by incorporating TFs gene expression data and deep learning … We
evaluate whether DeepCAGE can help recover continuous degree of chromatin accessibility

Integrating regulatory DNA sequence and gene expression to predict genome-wide chromatin accessibility across cellular contexts

S Nair, DS Kim, J Perricone, A Kundaje - Bioinformatics, 2019 - academic.oup.com
… Our study highlights the promise of integrative multi-modal deep learning models for learning
predictive models that generalize across cellular contexts and obtaining insight into the …

DeepCAGE: incorporating transcription factors in genome-wide prediction of chromatin accessibility

Q Liu, K Hua, X Zhang, WH Wong… - Genomics, Proteomics …, 2022 - academic.oup.com
… achieve interpretable annotations of chromatin accessibility across diverse cellular contexts.
To solve this problem, we propose DeepCAGE, a deep learning framework that integrates …

[HTML][HTML] Cancer classification based on chromatin accessibility profiles with deep adversarial learning model

H Yang, Q Wei, D Li, Z Wang - PLoS Computational Biology, 2020 - journals.plos.org
deep learning for the cancer molecular profiles analyses are relatively rare. It is mainly because
most deep learning networks are based on supervised learning … use of deep learning for …