Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation

MB Chandrasekharan, F Huang, ZW Sun - Epigenetics, 2010 - Taylor & Francis
… that the conjugation of ubiquitin onto H2B prevents H2A–H2B eviction and stabilizes the
nucleosome, and removal of the conjugated ubiquitin by deubiquitinases causes nucleosome …

Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability

MB Chandrasekharan, F Huang… - Proceedings of the …, 2009 - National Acad Sciences
… In this study, the role of H2Bub1 in regulating global chromatin … at the H2B C terminus
cannot functionally replace ubiquitination to support H3 methylation. Thus, the SUMO or ubiquitin

Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation

V Vethantham, Y Yang, C Bowman, P Asp… - … and cellular biology, 2012 - Taylor & Francis
… Several interesting questions arise as to how cells could bypass a requirement for detectable
levels of H2Bub in the regulation of gene expression and chromatin dynamics. Myogenic …

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

B Fierz, C Chatterjee, RK McGinty… - Nature chemical …, 2011 - nature.com
… intrinsic properties of the chromatin fiber to change the chromatin state. We used … that H2B
ubiquitylation (uH2B), a modification associated with transcription, interferes with chromatin

Effects of histone H2B ubiquitylation on the nucleosome structure and dynamics

WA Krajewski, J Li, Y Dou - Nucleic acids research, 2018 - academic.oup.com
H2B K34ub on nucleosome assembly and stability as well as the direct effects of H2B
ubiquitylation (K120 or K34) on nucleosome dynamics, … chromatin (45), which in turn deposits H2B

The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair

V Kari, A Shchebet, H Neumann, SA Johnsen - Cell cycle, 2011 - Taylor & Francis
chromatin dynamics during the DNA damage response and DNA repair. Our results suggest
that expression of the H2B ubiquitin … the induction of chromatin disassembly and reassembly …

Ubiquitination of histone H2B by proteasome subunit RPT6 controls histone methylation chromatin dynamics during memory formation

TJ Jarome, GA Perez, WM Webb, KM Hatch… - Biological …, 2021 - Elsevier
… in synaptic plasticity and long-term memory, and collectively our results suggest that H2B
ubiquitination is a regulator of histone methylation mechanisms that are critical for fear memory …

Post-translational modifications and chromatin dynamics

TO Tolsma, JC Hansen - Essays in Biochemistry, 2019 - portlandpress.com
chromatin dynamics in vitro and their effects on chromatin accessibility in vivo. We will discuss
both 30-nm fibers and chromatin … Considering H2B ubiquitination has a functional role in …

Histone sumoylation and chromatin dynamics

HY Ryu, M Hochstrasser - Nucleic Acids Research, 2021 - academic.oup.com
… implications for the control of chromatin dynamics (47). For … H2B mono-ubiquitylation (17),
while other evidence suggests that H2B and H4 sumoylation may require H2B ubiquitylation

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

T Ikura, S Tashiro, A Kakino, H Shima… - … and cellular biology, 2007 - Am Soc Microbiol
… Until recently, the biological significance of ubiquitination in the DNA damage response
has been unclear. H2B ubiquitination regulates the damage checkpoint response (Citation15). …