The chromatin landscape of healthy and injured cell types in the human kidney

DL Gisch, M Brennan, BB Lake, J Basta… - Nature …, 2024 - nature.com
… nucleus RNA expression and chromatin accessibility, DNA … the chromatin landscape and
gene regulation of the kidney in … kidney’s active, silent, and regulatory accessible chromatin

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

Z Miao, MS Balzer, Z Ma, H Liu, J Wu… - Nature …, 2021 - nature.com
… The human kidney cell type-specific open chromatin landscape showed consistent overlap
with multiple SNPs in multiple cell types (Fig. 6h). Interesting to note that one SNP with strong …

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

JM Simon, KE Hacker, D Singh, AR Brannon… - Genome …, 2014 - genome.cshlp.org
… for use on primary human clinical samples to define the chromatin landscape in a … -kidney-specific
classes of chromatin accessibility changes, as well as those associated with chromatin

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Y Muto, PC Wilson, N Ledru, H Wu, H Dimke… - Nature …, 2021 - nature.com
Chromatin accessibility profiling will help to identify distant regulatory regions … chromatin
accessibility can refine our understanding of cell state and function in the mature human kidney. …

Defining the dynamic chromatin landscape of mouse nephron progenitors

S Hilliard, R Song, H Liu, C Chen, Y Li… - Biology …, 2019 - journals.biologists.com
… In general, our findings are consistent with those of recent scRNA-seq studies of human
kidney development (Lindstrom et al., 2018; Menon et al., 2018; Wang et al., 2018) …

Chromatin accessibility analysis and architectural profiling of human kidneys reveal key cell types and a regulator of diabetic kidney disease

M Eun, D Kim, SI Shin, HO Yang, KD Kim, SY Choi… - Kidney International, 2024 - Elsevier
… accessibility profiling using healthy and DKD human adult kidneys To analyze the chromatin
landscape of kidney cell types, we performed snATAC-seq using adult kidney tissues from 6 …

Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants

A Duan, H Wang, Y Zhu, Q Wang, J Zhang, Q Hou… - BMC biology, 2021 - Springer
… Our results provide a valuable multi-omics resource on the chromatin landscape of human
kidney tubule cells and establish a bioinformatic pipeline in dissecting functions of kidney

Chromatin dynamics in kidney development and function

W Bechtel-Walz, TB Huber - Cell and tissue research, 2014 - Springer
… be expressed in human kidney mesangial cells and … kidney disease (Komohara et al. 2007).
A recent study links DNA hydroxymethylation and TET gene expression in the mouse kidney

SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes

Y Xie, M Sahin, S Sinha, Y Wang, AM Nargund, Y Lyu… - Nature cancer, 2022 - nature.com
chromatin accessibility to transcription factors and chromatin modifiers, which activates
enhancers and induces gene expression. Accordingly, an integrated ATAC-seq and ChIP–seq …

Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development

Y Yan, H Liu, A Abedini, X Sheng, M Palmer… - nature …, 2024 - nature.com
human kidney single-cell open chromatin changes in healthy and diseased kidneys, identifying
a large number of open chromatin … (methylation and open chromatin) changes in PT cells …