Strategies for large-scale targeted metabolomics quantification by liquid chromatography-mass spectrometry

J Zhou, Y Yin - Analyst, 2016 - pubs.rsc.org
quantification and untargeted metabolomics profiling, and have proven to be powerful tools
for metabolomics … widely in large-scale metabolomics quantification analysis due to its fast …

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives

MM Koek, RH Jellema, J van der Greef, AC Tas… - Metabolomics, 2011 - Springer
… for metabolomics analysis, metabolites are mostly quantified using relative quantification, ie
… in a sample can also be quantified using relative quantification. Metabonomics is sometime …

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

S Alseekh, A Aharoni, Y Brotman, K Contrepois… - Nature …, 2021 - nature.com
… While nuclear magnetic resonance (NMR) and capillary electrophoresis–mass spectrometry
… here on chromatography (either gas chromatography (GC) or liquid chromatography (LC)) …

A large-scale, targeted metabolomics method for the analysis and quantification of metabolites in human plasma via liquid chromatography-mass spectrometry

TS McMillen, A Leslie, K Chisholm, S Penny… - Analytica Chimica …, 2023 - Elsevier
… allows for more accurate quantification of metabolites by … metabolomic analysis strategy
capable of quantification of 540 metabolites in 40 min using comprehensive chromatographic

Discrimination and quantification of true biological signals in metabolomics analysis based on liquid chromatography-mass spectrometry

L Duan, I Molnár, JH Snyder, G Shen, X Qi - Molecular plant, 2016 - cell.com
quantification performance. Here, we report a novel strategy for a comprehensive LC-MS-based
metabolomics … signals, and improves the quantification accuracy of metabolites without …

… -labeled metabolomes allowing for improved compound annotation and relative quantification in liquid chromatography-mass spectrometry-based metabolomic …

P Giavalisco, K Köhl, J Hummel, B Seiwert… - Analytical …, 2009 - ACS Publications
… labeled metabolome is not only beneficial for high end mass spectrometers, … mass
spectrometry-based metabolomic platform. Metabolomics aims at the identification and quantification

Differential 12C-/13C-Isotope Dansylation Labeling and Fast Liquid Chromatography/Mass Spectrometry for Absolute and Relative Quantification of the Metabolome

K Guo, L Li - Analytical chemistry, 2009 - ACS Publications
… We report a new quantitative metabolome profiling technique based on … chromatography
(LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass

Higher mass loadability in comprehensive two-dimensional gas chromatographymass spectrometry for improved analytical performance in metabolomics analysis

MM Koek, B Muilwijk, LLP van Stee… - … of Chromatography A, 2008 - Elsevier
… in metabolomics analysis is the accurate quantification of metabolites in the presence of (extremely)
high abundant metabolites. Quantification … gas chromatographicmass spectrometric …

Plant metabolomics: resolution and quantification of elusive peaks in liquid chromatographymass spectrometry profiles of complex plant extracts using multi-way …

B Khakimov, JM Amigo, S Bak, SB Engelsen - Journal of Chromatography a, 2012 - Elsevier
… of PARAFAC2 for detection and quantification of elusive chromatographic peaks by solving
common chromatographic problems occurring in LC–MS metabolomic data. In this study, we …

QPMASS: a parallel peak alignment and quantification software for the analysis of large-scale gas chromatography-mass spectrometry (GC-MS)-based metabolomics …

L Duan, A Ma, X Meng, G Shen, X Qi - Journal of Chromatography A, 2020 - Elsevier
Gas chromatography-mass spectrometry (GC-MS) is a robust analytical platform for analysis
of small molecules. Recently, it is widely used for large-scale metabolomics studies, in …