… This difference may be explained by the presumed chronic elevation in brain Trp in shunts
which could be expected to result in greater accumulation of 5-HIAA as a result of chronically …

… This study confirms the indoleamine neuronal locations in the brain stem described by the
Swedish investigators, but in addition a number of other sites in the diencephalon - several …

… brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism,
plays a key role in this comorbidity. We found that chronic … induced by chronic social stress…

… In this study, we report that indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme
in tryptophan metabolism, plays a key role in epilepsy-associated depressive-like behavior. …

… the brain [17]. However, the study of the pathophysiological consequences of any prolonged
alteration in TRP metabolism requires a model of chronic brain … model of chronic brain IDO …

… Furthermore, we injected 1MT directly into the brain while Dobos and colleagues administered
1MT subcutaneously via a chronic release pellet or via injections without determining …

… although small increases in brain IDO activity and QUIN … chronic systemic administration
of y-IFN results in sustained increases in the activity of IDO and QUIN concentrations in brain…

… indoleamine metabolism in human brain and spinal cord. Our data suggested that (1) the
blood-brain … We have also found this in depressed patients on chronic tryptophan treatment.13 …

… degrading enzyme indoleamine 2,3 dioxygenase (IDO) in both the brain and periphery. IDO
… the plasma and brain of patients and animals following both acute and chronic stimulation of …

… effects of psychosocial stress as chronic social defeat (CSD) … tryptophan–kynurenine
catabolising enzyme indoleamine 2,3-… Nonetheless, oral IDOInh reduced blood and brain levels of …