Transdermal delivery of regular insulin to chronic diabetic rats: effect of skin preparation and electrical enhancement

CA Zakzewski, J Wasilewski, P Cawley… - Journal of controlled …, 1998 - Elsevier
insulin was delivered across the skin surface using a pulsed iontophoretic enhancement to
chronic diabetic BB/Wor rats… alert, conscious, in-bred chronic diabetic rats, indicate that these …

Left ventricular function after chronic insulin treatment in diabetic and normal rats

TF Schaible, A Malhotra, WA Bauman… - Journal of Molecular and …, 1983 - Elsevier
… hearts from rats made diabetic by streptozotocin for 6 weeks and then treated with insulin
for 3 weeks were compared … diabetic rats and control rats not injected with streptozotocin. …

[HTML][HTML] Short-and longterm glycemic control of streptozotocin-induced diabetic rats using different insulin preparations

G Luippold, J Bedenik, A Voigt, R Grempler - PloS one, 2016 - journals.plos.org
… The chemical induction of diabetes with STZ has gained popularity because of the relative
… of rendering normal animals diabetic. Insulin substitution is required in STZ-rats in long-term

Effect of insulin therapy on established diabetic nephropathy in rats

J Petersen, J Ross, R Rabkin - Diabetes, 1988 - Am Diabetes Assoc
Normal controls and diabetic rats were studied for 11 mo. During the first 6 mo, all the diabetic
rats received 2 U protamine zinc insulin … In this study, rats with severe diabetes developed …

Chronic exercise enhances insulin secretion ability of pancreatic islets without change in insulin content in non-diabetic rats

M Tsuchiya, Y Manabe, K Yamada, Y Furuichi… - Biochemical and …, 2013 - Elsevier
… that chronic exercise training significantly enhances the insulin secretion ability of pancreatic
islets upon high-glucose stimulation in normal non-diabetic rats. The insulin secretion of …

Control of glomerular hypertension by insulin administration in diabetic rats.

JW Scholey, TW Meyer - The Journal of clinical …, 1989 - Am Soc Clin Investig
Persistent elevation of SNGFR … insulin administration in group 2 diabetic rats increased Kf
to a value significantly greater than that observed in group 1 diabetic rats receiving no insulin

Myocardial composition and function in diabetes. The effects of chronic insulin use.

TJ Regan, CF Wu, CK Yeh, HA Oldewurtel… - Circulation …, 1981 - Am Heart Assoc
… of mild diabetes to determine if provision of chronic insulin … Group 1 served as controls
with normal glucose tolerance by … a diabetic rat preparation has been reduced to normal after …

Chronic insulin infusion suppresses food ingestion and body weight gain in rats

DA Vanderweele, FX Pi-Sunyer, D Novin… - Brain Research Bulletin, 1980 - Elsevier
… Average daily food intake for rats receiving 0, 1, 2, or 6 U regular insulin (short-acting) per …
-diabetic rats following exhaustion of the pump were analyzed for plasma glucose and insulin

Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes

S Apikoglu‐Rabus, FV Izzettin, P Turan… - Clinical and …, 2010 - academic.oup.com
… to impair the normal course of wound healing, thus leading to chronic wounds. The role of
insulin in the … Diabetic rats receiving topical insulin had higher rates of wound closure than the …

Impact of the type of continuous insulin administration on metabolism in a diabetic rat model

A Schaschkow, C Mura, S Dal… - Journal of diabetes …, 2016 - Wiley Online Library
… This large amount of insulin release could create chronic hyperinsulinism. This was highlighted
especially by the absence of glucose increase in the IpGTT test. Hyperinsulinism could …