… Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a … ,
the BCR-ABL1 oncogene. Decades of research zeroing in on the role of BCR-ABL1 kinase in …

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder resulting from the
clonal expansion of a transformed multipotent hematopoietic stem cell. CML is a biphasic …

… BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia
(CML)… Since tyrosine kinase activity is essential to the transforming function of BCR-ABL, an …

… Not all chronic myeloid leukemia (CML) patients are cured … Recently, continuous BCR-ABL
gene expression has been … Chronic myeloid leukemia (CML) is a clonal myeloproliferative …

… BCR-ABL expression is presumed to effect clonal expansion in chronic myeloid leukemia
(… We found that BCR-ABL expression inappropriately prolongs the growth factor-independent …

… Chronic myeloid leukemia (CML) is one of the most remarkable cancers. It was probably the
first type of leukemia … This led to the identification in CML cells of the BCR-ABL fusion gene …

… tyrosine kinase activity of the Bcr-Abl oncoprotein, all of which … chronic myelogenous
leukemia (CML) in the chronic phase. However, we still do not know for sure whether the BCR-ABL …

Purpose of review In this review, we emphasize up-to-date practical cytogenetic and
molecular aspects of chronic myeloid leukemia (CML) and summarize current knowledge on …

… BCr-ABL in chronic myeloid leukemia, including imatinib, dasatinib and nilotinib, have
dramatically improved patient outcome. BCR-ABL … Clinical data indicate that developing BCRABL …

… found that imatinib resistance was associated with the reactivation of BCR-ABL signal … the
BCR-ABL protein was the first mutation detected in imatinib resistant chronic myeloid leukemia …