[HTML][HTML] The NLRP3 inflammasome: an emerging therapeutic target for chronic pain

R Chen, C Yin, J Fang, B Liu - Journal of neuroinflammation, 2021 - Springer
chronic pain. Furthermore, we also discussed the mechanisms underlying NLRP3
inflammasome’s contribution to chronic pain… that target against NLRP3 inflammasome for chronic

[HTML][HTML] The NLRP3 inflammasome: Role in the pathobiology of chronic pain

C Chen, MT Smith - Inflammopharmacology, 2023 - Springer
… of neuropathic pain and/or chronic inflammatory pain. In this review, we address a role
for NLRP3 inflammasome activation in the pathogenesis of various chronic pain conditions. …

[HTML][HTML] The NLRP3 inflammasome: role and therapeutic potential in pain treatment

H Starobova, EI Nadar, I Vetter - Frontiers in Physiology, 2020 - frontiersin.org
Chronic pain is a dynamic process involving ongoing changes and adaption within the
peripheral and central nervous systems and accompanies a vast number of inflammatory and non…

NLRP3 inflammasome mediates neurodegeneration in rats with chronic neuropathic pain

C Ren, M Chen, G Mu, S Peng, X Liu, C Ou - Shock, 2021 - journals.lww.com
NLRP3 inflammasome is closely related to neuropathic pain. Study found that patients with
chronic pain … Another study shows that neurodegeneration can occur in rats with chronic pain

The NLRP3-related inflammasome modulates pain behavior in a rat model of trigeminal neuropathic pain

X Sun, L Cao, JL Ge, JY Ge, XF Yang, BX Du, J Song - Life Sciences, 2021 - Elsevier
NLRP3 in the medullary dorsal horn and variation of pain response behavior after silencing
the expression of NLRP3 inflammasome … of spontaneous chronic pain is different from the …

AMPK phosphorylation modulates pain by activation of NLRP3 inflammasome

P Bullón, E Alcocer-Gómez, AM Carrión… - Antioxidants & redox …, 2016 - liebertpub.com
… Since AMPK and the NLRP3 inflammasome pathway have … with pain symptoms through
NLRP3 inflammasome activation. … of AMPK/NLRP3-inflammasome axis in chronic pain and that …

The inflammasome as a target for pain therapy

H Zhang, F Li, WW Li, C Stary, JD Clark… - BJA: British Journal …, 2016 - academic.oup.com
… (part of the NLRP3 inflammasome complex in humans), ASC, and caspase-1. The NALP3
… 1–2% of the world’s population and is characterized by chronic pain, warmth, and swelling. …

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

PM Grace, KA Strand, EL Galer… - Proceedings of the …, 2016 - National Acad Sciences
… of chronic pain are enigmatic, in part due to the absence of preclinical studies. Furthermore,
the duration of OIH in either chronic pain … of opioid treatment; rather, pain was only assessed …

Albiflorin attenuates mood disorders under neuropathic pain state by suppressing the hippocampal NLRP3 inflammasome activation during chronic constriction injury

P Liu, J Chen, S Ma, J Zhang… - International Journal of …, 2021 - academic.oup.com
… This study examines the effect of albiflorin on the NLRP3 inflammasome, which … pain,
anxiety, and depression. We found that the NLRP3 inflammasome contributed to neuropathic pain

[HTML][HTML] The role of NLRP3 inflammasome in stroke and central poststroke pain

S Li, Y Zhang, S Ma, Y Yi, H Yu, L Pei, D Feng - Medicine, 2018 - journals.lww.com
NLRP3 inflammasome and CPSP. This review identifies a new insight of NLRP3 inflammasome
and … CPSP is considered as a group of chronic pain disorders, which are called central …