[HTML][HTML] Biogenesis, features, functions, and disease relationships of a specific circular RNA: CDR1as

Z Guo, Q Cao, Z Zhao, C Song - Aging and disease, 2020 - ncbi.nlm.nih.gov
CDR1as expression and that the CDR1as sequence is embedded in LINC00632 locus [31].
We speculate the pre-linear RNA of CDR1as … of the 5' and 3' ends to form the circular RNA. …

Diagnostic and prognostic value of circular RNA CDR1as/ciRS‐7 for solid tumours: A systematic review and meta‐analysis

Y Zou, S Zheng, X Deng, A Yang… - Journal of cellular …, 2020 - Wiley Online Library
circular RNA, CDR1as/ciRS‐7, functions as a vital regulator in various cancers; however, the
predictive value of CDR1as … diagnostic and prognostic value of CDR1as in solid tumours is …

The circular RNA Cdr1as act as an oncogene in hepatocellular carcinoma through targeting miR-7 expression

L Yu, X Gong, L Sun, Q Zhou, B Lu, L Zhu - PloS one, 2016 - journals.plos.org
Cdr1as expression was upregulated in HCC tissues compared with adjacent non-tumor tissues.
Knockdown of Cdr1as … knockdown of Cdr1as could suppress the Cdr1as expression (Fig …

Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

J Lou, Y Hao, K Lin, Y Lyu, M Chen, H Wang, D Zou… - Molecular cancer, 2020 - Springer
… In this study, the circRNA CDR1as has been identified to bind physically to p53 protein at
its core DBD. So far, only preliminary studies have been conducted to investigate the role of …

The role of circular RNA CDR1as/ciRS-7 in regulating tumor microenvironment: a pan-cancer analysis

Y Zou, S Zheng, X Deng, A Yang, X Xie, H Tang, X Xie - Biomolecules, 2019 - mdpi.com
Circular RNA CDR1as/ciRS-7 functions as an oncogenic … analysis of CDR1as among 868
cancer samples by using RNA-… Functional enrichment analysis suggested that CDR1as has …

The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10

X Yang, S Li, Y Wu, F Ge, Y Chen, Q Xiong - BMC cancer, 2020 - Springer
… We further confirmed this high CDR1as expression in 293 T cells via RNA FISH assessment,
determining that circRNA is localized to the cytoplasm (Fig. 1b). Next, a loss-of function …

Role of circular RNA cdr1as in modulation of macrophage phenotype

C Gonzalez, M Cimini, Z Cheng, C Benedict, C Wang… - Life sciences, 2022 - Elsevier
… In this study, we explored the role of circular RNAs in macrophage phenotypic switching. …
circular RNAs between pro−/anti-inflammatory macrophages and identify circular RNA Cdr1as

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

H Xu, S Guo, W Li, P Yu - Scientific reports, 2015 - nature.com
… of circular RNAs (circRNA) in humans and animals, Cdr1as (… Therefore, we infer that Cdr1as
expression may inhibit miR-7 … Here, we show the first characterization of Cdr1as expression …

Circular RNA CDR1as acts as a sponge of miR-135b-5p to suppress ovarian cancer progression

H Chen, M Mao, J Jiang, D Zhu, P Li - OncoTargets and therapy, 2019 - Taylor & Francis
Circular RNAs (circRNAs) play an important role in the development of various cancers, but
the … We aim to explore the function and mechanism of CDR1as in the progression of ovarian …

CiRS-7/CDR1as; An oncogenic circular RNA as a potential cancer biomarker

Y Rahmati, Y Asemani, S Aghamiri, F Ezzatifar… - … -Research and Practice, 2021 - Elsevier
RNA (ceRNA) with 70 binding sites [6] indicating why this name has been devoted to this
circRNA (circular RNA … As its name suggests, CDR1as is transcribed at the opposite direction to …