Dynamic interplay between cell membrane tension and clathrin‐mediated endocytosis

U Djakbarova, Y Madraki, ET Chan… - Biology of the Cell, 2021 - Wiley Online Library
… of cell membrane tension and the … that tension on the membrane is a fast-acting and
reversible regulator of CME. Finally, we discuss tension-based regulation of endocytic clathrin coat

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

S Boulant, C Kural, JC Zeeh, F Ubelmann… - Nature cell …, 2011 - nature.com
… We show that membrane tension determines the actin dependence of clathrin-coat … More
generally, if we raise membrane tension and inhibit actin dynamics, coated pits stall at a late …

Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis

D Bucher, F Frey, KA Sochacki, S Kummer… - Nature …, 2018 - nature.com
… of the final clathrin content is acquired. We find that this transition is marked by a change in
the clathrin to clathrin-adaptor protein AP2 ratio and that membrane tension suppresses this …

A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats

M Saleem, S Morlot, A Hohendahl, J Manzi… - Nature …, 2015 - nature.com
… Here, we show that membrane tension opposes clathrin polymerization. We reconstitute …
we find that clathrin coats cause extensive budding of GUVs under low membrane tension while …

Competing pathways for the invagination of clathrin-coated membranes

F Frey, US Schwarz - Soft Matter, 2020 - pubs.rsc.org
membrane tension, clathrin coats get more and more curved as they grow and finally end up
as spherical coats for large and intermediate coat … For low membrane tension clathrin coats

Membrane tension inhibits deformation by coat proteins in clathrin-mediated endocytosis

J Hassinger, D Drubin, G Oster, P Rangamani - Biophysical Journal, 2016 - cell.com
… We explore the mechanics of coat formation by simulating coats that either grow in area or
… When under low tension, addition of a curvature-generating coat causes the membrane to …

CALM supports clathrin-coated vesicle completion upon membrane tension increase

NM Willy, F Colombo, S Huber… - Proceedings of the …, 2021 - National Acad Sciences
… the local plasma membrane tension that varies during cell cycle, … membrane tension increase.
Since CALM is differentially expressed, our results demonstrate that competence in clathrin

Design principles for robust vesiculation in clathrin-mediated endocytosis

J Hassinger, G Oster, D Drubin, P Rangamani - Biophysical Journal, 2017 - cell.com
membrane remains essentially flat at high tensions. At intermediate, physiologically relevant,
tensions, the membranecoat area, spontaneous curvature or membrane tension cause the …

Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension

M Biancospino, GR Buel, CA Niño, E Maspero… - Nature …, 2019 - nature.com
… Importantly, CLCs appear essential at the apical surface of highly polarized tissues,
where membrane tension is higher than normal and actin dynamics is critical for membrane

Membrane mechanics govern spatiotemporal heterogeneity of endocytic clathrin coat dynamics

NM Willy, JP Ferguson, SD Huber… - Molecular biology of …, 2017 - Am Soc Cell Biol
… in cell membrane tension dominate the dynamics of clathrin-coatedmembrane tension,
that is, in-plane tension and membrane-cytoskeleton adhesion, to deform the plasma membrane