Clearance pathways and tumor targeting of imaging nanoparticles

M Yu, J Zheng - ACS nano, 2015 - ACS Publications
… Synergetic integration of effective renal clearance and EPR effect offers a promising pathway
to design low-toxicity and high-contrast-enhancement imaging nanoparticles that could …

Elimination pathways of nanoparticles

W Poon, YN Zhang, B Ouyang, BR Kingston, JLY Wu… - ACS …, 2019 - ACS Publications
… it is an FDA-approved tracer for hepatobiliary clearance. (20) We administered 50 nm AuNPs
… MATLAB was used to calculate the mean nanoparticle intensity from dark-field imaging of …

Degradability and clearance of inorganic nanoparticles for biomedical applications

G Yang, SZF Phua, AK Bindra, Y Zhao - Advanced Materials, 2019 - Wiley Online Library
… The clearance of nanoparticles follows two main pathways in … Nanoparticles with the sizes
exceeding 6 nm or containing … nanoparticles (HA-SiNPs) for specific delivery and imaging

Conjugated polymer nanoparticles toward in vivo theranostics–focus on targeting, imaging, therapy, and the importance of clearance

AJC Kuehne - Advanced Biosystems, 2017 - Wiley Online Library
… When we look at existing nonconjugated polymer drug delivery vehicles, we realize that a
wide variety of degradation and clearance pathways has been described. The degradation of …

Clearance of two organic nanoparticles from the brain via the paravascular pathway

X Gu, Q Song, Q Zhang, M Huang, M Zheng… - Journal of Controlled …, 2020 - Elsevier
… As expected, in CX3CR1-GFP transgenic mice where microglia are GFP labeled, utilizing
two-photon microscopy for in vivo imaging, we visualized that microglia efficiently captured …

[PDF][PDF] Imaging nano-bio interactions in the kidney: toward a better understanding of nanoparticle clearance

J Wang, G Liu - Angew. Chem., Int. Ed, 2018 - academia.edu
… nano–bio interactions for rational design of renalclearable nanoparticles in diseased kidneys.
Renal clearance of ultra-small gold nanoparticles (AuNPs) is not only dependent upon the …

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

M Longmire, PL Choyke, H Kobayashi - Nanomedicine, 2008 - Taylor & Francis
clearance properties. This article presents a thorough discussion of the physiologic aspects
of nanoparticle clearance, … represents a desirable pathway for NP/NM clearance as the …

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
clearance pathway, the filter-like structures of the liver and kidneys also control nanoparticle
… /light dual-responsive monochromatic ratiometric imaging nanoparticle (MRIN) that enables …

Factors Relating to the Biodistribution & Clearance of Nanoparticles & Their Effects on In Vivo Application

Y Wei, L Quan, C Zhou, Q Zhan - Nanomedicine, 2018 - Taylor & Francis
… are subject to several possible metabolic pathways, including the dissolution and release of
soluble … and maintain the unique properties for cancer imaging, making larger nanoparticles

Clearance Pathways and Tumor Targeting of Imaging Nanoparticles for Diagnostics

PK Parikh, NH Parikh, JK Patel, YV Pathak - … and Pharmacodynamics of …, 2022 - Springer
… In the present compilation, clearance pathway and tumor targeting of imaging nanoparticles
… , and surface charge of NPs on their clearance is discussed. Tumor targeting strategies, ie, …