… of nasal drug formulations. Nasal mucociliary clearance also has implications for nasal drug
… Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in …

… Drug absorption after intranasal administration depends on the nasal residence of the
drug, which is determined by nasal mucociliary clearance (MC). The primary function of MC is …

… clearance rates differed between the clear and the obstructed airway at a morning peak of
the nasal … of deposition produced by the nasal administration devices were determined. The …

… nasal administration in a physiological volume of fluid, they did not take into account the
clearance … provided a drug clearance rate that best agreed with the measured in vivo data (18). …

… The same materials were also studied for their effect on decreasing the nasal clearance
rate of microspheres administered nasally to rats.The effect was most pronounced for MC (3%) …

… might, therefore, affect the absorption profile of nasally administered drugs. Several approaches
have been successfully used to reduce the clearance rate. A drug deposited in the nose …

… ) in vitro, yet the clearance rates in vivo were usually reduced. The clearance rates returned
to normal … lowing the administration of lidocaine HC1 (Fig. la) where a significant decrease in …

… distal part of the nasal cavity. In the … clearance rate of both preparations (P > 0.05), therefore
it could be claimed that both liposomes were able to interact with mucosal surfaces of nasal …

… in the nasal cavity thereby providing the potential for improved systemic medication. The nasal
clearance rates … against the animal sneezing during nasal administration, the sheep were …

… for nasal administration. For example, it has been demonstrated that factors such as the
administration … The clearance rate from the nasal cavity is shown in Figure 4. As the images were …