DNA methylation based biomarkers: practical considerations and applications

AH Kit, HM Nielsen, J Tost - Biochimie, 2012 - Elsevier
… , which is of great potential for many applications. This stable … In some cases, DNA methylation
based biomarkers have … is to discuss the advantages of DNA methylation as a biomarker, …

Molecular diagnostic applications of DNA methylation technology

SE Cottrell - Clinical biochemistry, 2004 - Elsevier
… analysis of patterns of methylation across the genome … DNA methylation-based molecular
diagnostic assays are particularly attractive because of the stability of the target analyte (DNA

Profiling DNA methylation based on next-generation sequencing approaches: new insights and clinical applications

D Barros-Silva, CJ Marques, R Henrique, C Jerónimo - Genes, 2018 - mdpi.com
DNA methylation profiles can also be inherited through cell division … DNA methylation to
answer biological questions has been highlighted. Moreover, uncovering of DNA methylation

Clinical applications of DNA methylation biomarkers in colorectal cancer

CPE Lange, PW Laird - Epigenomics, 2013 - Taylor & Francis
… In recent years, abnormal patterns of DNA methylation have … of DNA methylation biomarkers
in CRC clinical applications. … blood-based MLH1 DNA methylation assay. Another example …

DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine

N Fatemi, S Tierling, HA Es, M Varkiani… - … journal of cancer, 2022 - Wiley Online Library
… Hence, the drugs that inhibit DNA methylation must be … highlight clinical applications of DNA
methylation biomarkers … expanding evidence that supports DNA methylation changes as a …

A summary of the biological processes, disease-associated changes, and clinical applications of DNA methylation

GB Andersen, J Tost - DNA Methylation Protocols, 2018 - Springer
… pathologies for which changes in DNA methylation patterns have been investigated will be
… much of the DNA methylation literature on clinical applications of DNA methylation changes …

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

Nature biotechnology, 2016 - nature.com
DNA methylation assays that are sufficiently fast, cheap, robust and widely available to be
useful for routine clinical … for measuring DNA methylation in large cohorts, clinical diagnostics …

DNA methylation-based predictors of health: applications and statistical considerations

PD Yousefi, M Suderman, R Langdon… - Nature Reviews …, 2022 - nature.com
… of DNA methylation-based predictors across a wide range of health-related applications,
from the … This Review evaluates the progress of existing DNA methylation-based predictors, …

Cancer DNA methylation: molecular mechanisms and clinical implications

MT McCabe, JC Brandes, PM Vertino - Clinical Cancer Research, 2009 - AACR
… Thus far, clinical applications of epigenetic therapy have primarily focused on nucleoside
analog inhibitors of the DNMTs, alone (95) and in combination with HDAC inhibitors (95–98). …

Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications

IR Miousse, KR Kutanzi, I Koturbash - International journal of …, 2017 - Taylor & Francis
… elements and gene-specific DNA methylation in light of … DNA methylation and discuss ways
in which that understanding can be applied clinically, including utilization of DNA methylation