… Remarkably few treatments are proved to be highly and consistently effective in acute
episodes of bipolar depression, and there is even less evidence supporting substantial long-term …

… Bipolar depression and its clinical presentation is a frequent but … and the clinical and economic
relevance of bipolar depression, … In practice, the treatment of bipolar depression typically …

… is the dearth of randomized controlled evidence for the treatment of bipolar depression,
resistant to at least two treatment steps. This paucity of evidence contrasts starkly with the high …

… There is some evidence to suggest that bipolar depression is poorly responsive to existing
therapies. Frankle et al. (11), in a retrospective review of the chart notes of 165 outpatients …

… overlap, though there is some evidence of greater impairment in bipolar disorder. Both …
some evidence of worse executive functioning in bipolar-depressed subjects (36). Patients with …

… Despite limited evidence of their efficacy in bipolar depression, 71 –82 such agents appear
to be preferred largely for their safety, especially in acute overdoses among patients at high …

… is inflicted by depressive phases (bipolar depression) both in … evidence for the underdiagnosis
of bipolar depression and its … There is currently less robust evidence for the appropriate …

… The group rather took into account the cumulative evidence in the area of bipolar
depression, from diagnostic issues to new developed medications. The group defined …

This article attempts to summarize the current status of our knowledge and practice in the
acute treatment and prophylaxis of bipolar depression. For prophylactic treatment, our …

… evidence regarding acute bipolar depression is not supportive of lithium monotherapy, but
as it is a recalcitrant condition with a substantial suicide risk, adjunctive treatment with this …