The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis

MMJ Wijnenga, PJ French, HJ Dubbink… - Neuro …, 2018 - academic.oup.com
… In 39 (17.1%) histopathologically classified gliomas, the subtype was revised after molecular
analysis. Complete resection was achieved in 35 patients (15.4%), and in 54 patients (23.7…

[HTML][HTML] Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

TL Stockley, AM Oza, HK Berman, NB Leighl, JJ Knox… - Genome medicine, 2016 - Springer
… The clinical utility of molecular profiling of tumor tissue to … , clinical “actionability” of somatic
variants, enrollment in mutation-targeted or other clinical trials, and outcome of molecular

[HTML][HTML] Analytical validation of the next-generation sequencing assay for a nationwide signal-finding clinical trial: molecular analysis for therapy choice clinical trial

CJ Lih, RD Harrington, DJ Sims, KN Harper… - The Journal of Molecular …, 2017 - Elsevier
… called the Molecular Analysis for Therapy Choice (referred to as NCI-MATCH) that is
conducted through the National Clinical Trial Network and National Clinical Oncology Research …

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

R Cristescu, J Lee, M Nebozhyn, KM Kim, JC Ting… - Nature medicine, 2015 - nature.com
… We aim to establish clinically relevant molecular subtypes … clinical information. We use
gene expression data to describe four molecular subtypes linked to distinct patterns of molecular

Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact

J Garbino, MW Gerbase, W Wunderli… - American journal of …, 2004 - atsjournals.org
… with significant clinical impact strongly suggests that the timely use of PCR-based assays,
followed by appropriate antiviral treatment, may have a determinant impact on clinical care …

Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: an Italian multicenter study

A Plebani, A Soresina, R Rondelli, GM Amato… - Clinical …, 2002 - Elsevier
… -based retrospective clinical and immunological survey was conducted in 73 males with a
definite diagnosis of X-linked agammaglobulinemia based on BTK sequence analysis. Forty-…

The impact of molecular genetic analysis of theVHL gene in patients with haemangioblastomas of the central nervous system

S Gläsker, BU Bender, TW Apel, E Natt… - Journal of Neurology …, 1999 - jnnp.bmj.com
… in our clinic agreed to molecular genetic testing for germline mutations of theVHL gene and
were included in our register. Another 89 patients consulted us for molecular genetic testing. …

Initiative for molecular profiling and advanced cancer therapy (IMPACT): an MD Anderson precision medicine study

AM Tsimberidou, DS Hong, Y Ye, C Cartwright… - JCO precision …, 2017 - ascopubs.org
… patients who were referred to the phase I clinical trials program from February 2012 to October
2013 and who underwent molecular analysis, per previously described methodology. All …

Arrhythmogenic right ventricular cardiomyopathy/dysplasia: clinical impact of molecular genetic studies

D Corrado, G Thiene - Circulation, 2006 - Am Heart Assoc
molecularclinical impact of genotype determination includes diagnosis (family screening
and preclinical diagnosis); prediction of clinical phenotype (penetrance, gene-specific clinical

Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non–small-cell lung cancer

G Simon, A Sharma, X Li, T Hazelton… - Journal of Clinical …, 2007 - ascopubs.org
… assigned to the different chemotherapies, but rather that molecular analysis directed
individualized chemotherapy assignment is feasible and yields promising results in outcomes. …