The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation

D Malkawi, K Savsani, A Alfonso, SD Lee, N James… - Livers, 2023 - mdpi.com
Marginal liver grafts, or grafts from extended criteria donors (ECD), that would have been
previously discarded are becoming an increasingly essential part of the organ donor pool [18]. …

Two compartment evaluation of liver grafts during acellular room temperature machine perfusion (acRTMP) in a rat liver transplant model

N Abraham, M Zhang, P Cray, Q Gao, KP Samy… - Frontiers in …, 2022 - frontiersin.org
… the ability to perform viability testing of marginal liver grafts. In contrast, under normothermic
… In order to use machine perfusion as a platform to assess the viability of marginal liver grafts

Current status of liver transplantation using marginal grafts

A Badawy, T Kaido, S Uemoto - Journal of Investigative Surgery, 2020 - Taylor & Francis
… To solve that problem, the use of marginal liver grafts has become an inevitable choice.
The criteria of marginal liver grafts or extended criteria donor (ECD) have not been definitely …

Use of a new modified HTK solution for machine preservation of marginal liver grafts

J Stegemann, A Hirner, U Rauen, T Minor - Journal of Surgical Research, 2010 - Elsevier
… first experimental evidence for enhanced organ protective potential of the new Custodiol-N
solution compared with HTK upon hypothemic machine preservation of marginal liver grafts. …

[HTML][HTML] Current and Future Applications of Machine Perfusion and Other Dynamic Preservation Strategies in Liver Transplantation

Y Qiu, Y Kang, H Liu, I Hilmi - OBM Transplantation, 2024 - lidsen.com
… This review summarizes the findings from clinical trials on hypothermic MP, normothermic
MP (NMP), explores novel dynamic preservation approaches, such as normothermic regional …

Advances in the management of the explanted donor liver

M Nebrig, P Neuhaus, A Pascher - Nature Reviews Gastroenterology & …, 2014 - nature.com
… Determination of the clinical significance of these new systems is a topic worthy of … clinical
interventions on the potential donor. Standard pretreatment regimens to counteract the effects

Does machine perfusion improve immediate and short‐term outcomes by enhancing graft function and recipient recovery after liver transplantation? A systematic …

A Ramírez‐Del Val, J Guarrera, RJ Porte… - Clinical …, 2022 - Wiley Online Library
… ) for marginal liver grafts. Their effect on enhanced recovery, however, remains uncertain. …
To mitigate the effects of using ECD organs, clinicians and medical device companies have …

A systematic review and meta-analysis of machine perfusion vs. static cold storage of liver allografts on liver transplantation outcomes: the future direction of graft …

J Jia, Y Nie, J Li, H Xie, L Zhou, J Yu… - Frontiers in medicine, 2020 - frontiersin.org
… (ECDs), living liver donation, or marginal liver grafts are increasingly accepted to expand the
limited … to protect or rescue marginal liver grafts by attenuating the cytokine mediated IRI (3). …

Combined organ transplantation in patients with advanced liver disease

IW Zhang, I Lurje, G Lurje, C Knosalla… - Seminars in Liver …, 2024 - thieme-connect.com
Transplantation of the liver in combination with other organs is an increasingly performed
procedure. Over the years, continuous improvement in survival could be realized through …

[PDF][PDF] Development and validation of a model predicting graft survival after liver transplantation

GN Ioannou - Liver transplantation, 2006 - Wiley Online Library
This study aimed to develop and validate a comprehensive model that predicts survival after
liver transplantation based on pretransplant donor and recipient characteristics. Complete …