Antiviral drug resistance: mechanisms and clinical implications

L Strasfeld, S Chou - Infectious Disease Clinics, 2010 - id.theclinics.com
… Prolonged antiviral drug exposure and ongoing … drug resistance, which may manifest as
persistent or increasing viremia or disease despite therapy. Consequences of drug resistance

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

T Shibue, RA Weinberg - Nature reviews Clinical oncology, 2017 - nature.com
… limited by the development of drug resistance. Such acquired resistance is driven, in part, …
a possible mechanistic basis for anticancer drug resistance. In fact, accumulating evidence …

Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a TBNET/RESIST-TB consensus statement

J Domínguez, EC Boettger, D Cirillo… - … of tuberculosis and …, 2016 - ingentaconnect.com
… tuberculosis has implications for the … detecting resistance-associated mutations in drugs
for which there is poor or unproven correlation between phenotypic and clinical drug resistance

Clinical implications of the phenomenon of drug resistance

JH Goldie, AJ Coldman - Drug and hormone resistance in …, 2019 - taylorfrancis.com
… ratio between drug sensitive and drug resistant cells. If the proportion of drug resistant cells
is quite low and if the treatment given falls well short of eradicating all of the drug sensitive …

Clinical implications of drug resistance

HMW Verheul, HM Pinedo - Cambridge University Press …, 1998 - books.google.com
1. Tumor types in which a large fraction of patients can be cured. Here we should differentiate
between those patients with advanced disease and those treated in an adj uvant setting …

Cytomegalovirus drug resistance and clinical implications

SW Chou - Transplant Infectious Disease, 2001 - Wiley Online Library
… isolates often contain multiple resistance mutations. A limitation of genotypic assays is that
drug resistance and risk factors Much of our existing knowledge about CMV drug resistance

Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management

MS Hirsch, B Conway, TD Richard, VA Johnson… - Jama, 1998 - jamanetwork.com
… The italicized letter below the residue indicates the substitution that confers drug resistance.
The drug-… To review current knowledge of the biology and clinical implications of human …

Molecular mechanisms and clinical implications of miRNAs in drug resistance of colorectal cancer

L Duan, W Yang, W Feng, L Cao… - Therapeutic …, 2020 - journals.sagepub.com
drug resistance in CRC. Certain of these miRNAs may thus be used as promising biomarkers
for predicting drug … We also discuss the potential role of drug resistance-related miRNAs as …

Antiplatelet drug resistance: Molecular insights and clinical implications

CN Floyd, A Ferro - Prostaglandins & other lipid mediators, 2015 - Elsevier
… that are known to confer resistance. Here we present molecular insights into the mechanisms
for aspirin and clopidogrel resistance, with a discussion of their clinical implications. …

Clinical implications of multi-drug resistance in the intensive care unit

DR Snydman - Scand J Infect Dis, 1991 - Taylor & Francis
… However, the frequency of cross-resistance and the development of resistance to fJ-lactams …
, many clinicians are not generally aware of the clinical implications of cross-resistance. Addi…