[HTML][HTML] Rare mutations in cancer drug resistance and implications for therapy
RA Beckman, LA Loeb - Clinical pharmacology and therapeutics, 2020 - ncbi.nlm.nih.gov
Intratumoral genetic heterogeneity is well known, as is the role of preexisting mutations in
many documented cases of clinical relapse. But what is the extent of diversity and how does it …
many documented cases of clinical relapse. But what is the extent of diversity and how does it …
Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management
AMJ Wensing, DA Van De Vijver… - The Journal of …, 2005 - academic.oup.com
… drug-resistant human immunodeficiency virus type 1 (HIV-1) can impair the response to
combination therapy. Widespread transmission of drug-resistant … rate of drug resistance in 2208 …
combination therapy. Widespread transmission of drug-resistant … rate of drug resistance in 2208 …
Public health implications of antiretroviral therapy and HIV drug resistance
MA Wainberg, G Friedland - Jama, 1998 - jamanetwork.com
… of prevalence of HIV drug resistance in both treatment-naive and drug-experienced groups.
In the meantime, prevention of both occurrence and transmission of drug-resistant HIV is …
In the meantime, prevention of both occurrence and transmission of drug-resistant HIV is …
Clinical implications of HIV-1 minority variants
JZ Li, DR Kuritzkes - Clinical infectious diseases, 2013 - academic.oup.com
… study of antiretroviral drug resistance and are increasingly moving from the laboratory to
clinical practice. These techniques are able to detect HIV-1 drug resistance mutations present at …
clinical practice. These techniques are able to detect HIV-1 drug resistance mutations present at …
[HTML][HTML] Cancer stem cells and immunoresistance: clinical implications and solutions
J Codony-Servat, R Rosell - Translational lung cancer research, 2015 - ncbi.nlm.nih.gov
… Finally, a minor attack-resistant subpopulation escapes and forms a clinically detectable …
Due to the correlation between CTCs/TICs and drug resistance and metastasis, we also …
Due to the correlation between CTCs/TICs and drug resistance and metastasis, we also …
Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
TC White, KA Marr, RA Bowden - Clinical microbiology reviews, 1998 - Am Soc Microbiol
… drug resistance in the early 1980s, we have accumulated a body of knowledge concerning
the clinical… Recently, an elucidation of the molecular aspects of antifungal drug resistance has …
the clinical… Recently, an elucidation of the molecular aspects of antifungal drug resistance has …
Transport of topoisomerase I inhibitors by the breast cancer resistance protein: potential clinical implications
JHM Schellens, M Maliepaard… - Annals of the New …, 2000 - Wiley Online Library
… P-gp has also been widely associated with clinical drug resistance in preclinical models.
Overexpression of P-gp results in a significantly increased drug efflux and therefore decreased …
Overexpression of P-gp results in a significantly increased drug efflux and therefore decreased …
The genetic origin of drug resistance in neoplasms: implications for systemic therapy
JH Goldie, AJ Coldman - Cancer research, 1984 - AACR
… such as pleiotropic drug resistance are providing insights into how multiple levels of drug
resistance occur and are yielding information on how certain types of drug resistance may be …
resistance occur and are yielding information on how certain types of drug resistance may be …
Hepatitis B virus resistance to antivirals: clinical implications and management
F Zoulim - Journal of Hepatology, 2003 - Elsevier
… of clinical trials and independent studies, clinicians have … of the incidence of drug resistance
and its clinical consequences. … resistance and the clinical consequences of viral resistance. …
and its clinical consequences. … resistance and the clinical consequences of viral resistance. …
Drug resistance in human cancers—Mechanisms and implications
S Vijayakumar, R Dhakshanamoorthy, A Baskaran… - Life Sciences, 2024 - Elsevier
… receptors and increased drug efflux. We present here comprehensively the drug resistance
in cancers … Also, apart from resistance to regularly used chemotherapeutic drugs, we present …
in cancers … Also, apart from resistance to regularly used chemotherapeutic drugs, we present …