In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has received
enthusiastic investigation, and significant progress has been made toward understanding …

Oxygen maintains the homeostasis of an organism in a delicate balance in different tissues
and organs. Under hypoxic conditions, hypoxia-inducible factors (HIFs) are specific and …

… Most of the other molecular targets discussed in this Review are still in clinical or
preclinical stages of development. If trials are successful, clinicians will certainly welcome the …

… biological and clinical features. We discuss the latest advances in the molecular basis of
nucleophosmin traffic under physiological conditions, describe the molecular abnormalities …

… renal function can be assessed with relative ease in clinical practice and has been quantified
in longitudinal studies [2]. The molecular basis of ageing changes in organs is not known, …

Protein kinases are one of the most studied drug targets in current pharmacological research,
as evidenced by the vast number of kinase-targeting agents enrolled in active clinical trials…

… In this review, we introduce the mechanisms and molecular bases of ceRNA networks,
discuss their roles in the pathogenesis of cancer as well as methods of predicting and validating …

… We will briefly illustrate the progress in molecular genetics of heritable skin diseases and its
clinical implications by discussing two illustrative conditions, the dystrophic forms of …

… This review discusses recent advances in our understanding of how adaptive immunity
contributes to the pathogenesis of ACS and the clinical implications that arise from these new …

… The aim of this review is to summarize the current knowledge regarding the molecular
mechanisms of this bidirectional crosstalk and to highlight its clinical implications. …