… This review will discuss the clinical features of … known diagnosis of amyloidosis to be
investigated for a clinical or subclinical neuropathy. Initially, patients may only have clinical features …

… collected in THAOS on the clinical characteristics of a large group of patients with hereditary
and wild-type TTR amyloidosis (n = 967). Findings highlight the considerable phenotypic …

… Clinical Features of Transthyretin Amyloidosis Peripheral neuropathy is the major clinical
manifestation of transthyretin amyloidosis‘. This was the basis for naming the syndrome familial …

… of the fibrils and by the clinical features of the disease. … Diagnosis of SSA is confirmed by
histological demonstration of transthyretin amyloid in the heart in the absence of TTR mutations. …

… The diagnosis of hereditary ATTR amyloidosis is established in a proband with characteristic
clinical features, amyloid deposits identified on biopsy that bind to anti-TTR antibodies, and …

… 2 When wild-type TTR (TTRwt) is deposited in greater amounts in the … to clinical manifestation,
wild-type transthyretin amyloidosis (ATTRwt), also known as senile systemic amyloidosis, …

… recommended by the International Society of Amyloidosis (ISA) to modify the … in clinical
presentation [32]. SSA was renamed as wild-type amyloid TTR amyloidosis (ATTRwt amyloidosis)…

… appearance of symptoms associated with amyloidosis [35]. … the first detection of amyloid
deposition and symptom onset in … Notably, the clinical features of acquired ATTR amyloidosis …

… In ATTR-CM, TTR amyloid fibrils in the myocardium cause diastolic dysfunction and eventual
symptomatic heart failure [4]. A recent study has shown that the number of patients with wild…

… clinical presentation Wild type ATTR-CA (ATTRwt-CA), previously known as senile systemic
amyloidosis, is caused by age-related misfolding of TTR, … form of TTR amyloid in Europe and …