Real-World Response and Outcomes in Patients With NSCLC With EGFR Exon 20 Insertion Mutations
… This study described treatment patterns and clinical outcomes among patients with …
This study also found that 1L IO treatment, either as monotherapy or in combination with …
This study also found that 1L IO treatment, either as monotherapy or in combination with …
EGFR exon 20 insertions in advanced non-small cell lung cancer: A new history begins
… either agent alone, with similar IC 50 with the combination regardless of the EGFR TKI
subtype [20]. However, clinical evidence for this combination is limited [34], [35]. Two ongoing …
subtype [20]. However, clinical evidence for this combination is limited [34], [35]. Two ongoing …
EGFR exon 19 deletion mutations and systemic/central nervous system miliary metastasis: clinical correlations and response to therapy
… hybridization was negative for either gene rearrangement. … may be predictive for improved
outcomes for leptomeningeal … improved clinical outcomes when compared with EGFR exon 21 …
outcomes for leptomeningeal … improved clinical outcomes when compared with EGFR exon 21 …
Impact of Exon 19 Deletion Subtypes in EGFR-Mutant Metastatic Non–Small-Cell Lung Cancer Treated With First-Line Tyrosine Kinase Inhibitors
S Rossi, L Toschi, G Finocchiaro, V Di Noia… - Clinical Lung Cancer, 2019 - Elsevier
… The frequency of uncommon deletions of exon 19 was 36%. When delE746_A750 (n = 68)
was compared to the other deletions in exon 19 (n = 38), no differences were found, either in …
was compared to the other deletions in exon 19 (n = 38), no differences were found, either in …
Adjuvant imatinib in patients with GIST harboring exon 9 KIT mutations: results from a multi-institutional European retrospective study
… In this multi-institutional retrospective case series analysis of 185 patients with KIT exon 9–mutated
GIST who received adjuvant imatinib either at 400 mg per day or 800 mg per day, …
GIST who received adjuvant imatinib either at 400 mg per day or 800 mg per day, …
The Clinical Outcome Study for dysferlinopathy: An international multicenter study
E Harris, CL Bladen, A Mayhew, M James… - Neurology …, 2016 - AAN Enterprises
Objective: To describe the baseline clinical and functional characteristics of an international
cohort of 193 patients with dysferlinopathy. Methods: The Clinical Outcome Study for …
cohort of 193 patients with dysferlinopathy. Methods: The Clinical Outcome Study for …
Defective splicing, disease and therapy: searching for master checkpoints in exon definition
… These factors can bind particular enhancer and silencer sequences either within the
exon itself (ESE and ESS) or in the nearby flanking regions (ISE and ISS) and help increase/…
exon itself (ESE and ESS) or in the nearby flanking regions (ISE and ISS) and help increase/…
[HTML][HTML] ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes
I Zighelboim, AP Schmidt, F Gao… - Journal of Clinical …, 2009 - ncbi.nlm.nih.gov
… However, some patients will either present with advanced-stage disease or … in exon 10 of
ATR would be associated with more aggressive phenotypes and worse clinical outcomes. The …
ATR would be associated with more aggressive phenotypes and worse clinical outcomes. The …
Single base‐pair substitutions in exon–intron junctions of human genes: nature, distribution, and consequences for mRNA splicing
M Krawczak, NST Thomas, B Hundrieser… - Human …, 2007 - Wiley Online Library
… Virtually all of these mutations cause either exon skipping or cryptic splice-site utilization,
resulting in the severe reduction or absence of normally spliced mRNA. In addition, mutations …
resulting in the severe reduction or absence of normally spliced mRNA. In addition, mutations …
[HTML][HTML] PD-L1 expression, tumor mutational burden, and response to immunotherapy in patients with MET exon 14 altered lung cancers
… In an expansion cohort of patients with MET exon 14 alterations on the … exon 14-altered
lung cancers of any stage who were identified between 1 January 2014 and 1 May 2017 at either …
lung cancers of any stage who were identified between 1 January 2014 and 1 May 2017 at either …