[PDF][PDF] Strain-and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy

LR Kalan, JS Meisel, MA Loesche, J Horwinski… - Cell host & …, 2019 - cell.com
… metagenomics allows for strain-level tracking and functional annotation, which both revealed
aspects of the DFU microbiome and its association with clinical outcomes in this study. …

Clinical outcomes of patients with advanced gastrointestinal stromal tumors: Safety and efficacy in a worldwide treatment‐use trial of sunitinib

P Reichardt, YK Kang, P Rutkowski, J Schuette… - Cancer, 2015 - Wiley Online Library
… Post hoc analyses were performed to evaluate patients' clinical outcomes after stratification
based on patterns of sunitinib dosing that emerged during the study. In 1 analysis, patients …

Patient subsets and variation in therapeutic efficacy.

R Simon - British Journal of Clinical Pharmacology, 1982 - Wiley Online Library
… Ideally, medical trials should yield reliable and precise predictions of clinical outcomes as
a … to what extent it is useful as a basis for designing randomized therapeutic clinical trials. …

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

D Bruni, HK Angell, J Galon - Nature Reviews Cancer, 2020 - nature.com
… , as well as patient outcome, are estimated on the basis of this staging system for a variety
of cancers 1,2,3 . However, significant differences in clinical outcome are observed in patients …

The design of clinical studies to assess therapeutic efficacy in multiple sclerosis

JR Brown, GW Beebe, JF Kurtzke, RB Loewenson… - Neurology, 1979 - AAN Enterprises
… The hypothesis should be kept simple, however, for the pilot trial should answer only one
question: Does the new therapy seem to have greater therapeutic efficacy than the standard …

Pathologic predictors of renal outcome and therapeutic efficacy in IgA nephropathy: validation of the oxford classification

SF Shi, SX Wang, L Jiang, LV Ji-Cheng… - Clinical Journal of the …, 2011 - journals.lww.com
… lesion and clinical outcomes. Univariate Cox regression was used to determine factors
predicting clinical outcomes; pathology variables associated with outcomes were further studied …

Efficacy, safety, and clinical outcomes of endoscopic mucosal resection: a study of 101 cases

NA Ahmad, ML Kochman, WB Long, EE Furth… - Gastrointestinal …, 2002 - Elsevier
… The aim of this study was to assess the safety, efficacy, and clinical outcomes of EMR. …
or ablation therapy for neoplastic lesions. The safety, efficacy, and clinical outcomes of EMR …

… clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan: one-year clinical outcomes  …

Y Tanaka, T Takeuchi, E Inoue, K Saito… - Modern …, 2008 - academic.oup.com
… In conclusion, we reconfirmed the clinical efficacy of infliximab and demographic factors
related to the efficacy over a 54-week study period in 410 Japanese patients with RA using …

The contribution of models and techniques to therapeutic efficacy: Contradictions between professional trends and clinical research.

BM Ogles, T Anderson, KM Lunnen - 1999 - psycnet.apa.org
Contradict ions Between Professional Trends and Clinical Research t first glance, this chapter
may seem out of place. Why would a book with a focus on the common factors-the" heart …

Clinical outcomes after ablation and pacing therapy for atrial fibrillation: a meta-analysis

MA Wood, C Brown-Mahoney, GN Kay… - Circulation, 2000 - Am Heart Assoc
… of morbidity and mortality related to the therapy. The findings of this meta-analysis with effect
sizes for clinical outcomes may facilitate the design of future trials to address these issues. …