… (BET) family and is an epigenetic reader playing diverse roles in regulating transcriptional
… to advance our understanding of the epigenetic mechanisms in vascular diseases during …

… In this review, we have focused on comprehending the concepts associated with epigenetic
writers, readers and erasers. The recent developments in targeting these tools for cancer …

… in clinical trials, the targeting of epigenetic readers has lagged behind. Proof-of-principle that
epigenetic readers … druggable epigenetic readers before discussing more difficult targets. …

… the enzymes that deposit epigenetic marks (writers) or remove epigenetic marks (erasers),
and drug discovery targets now include the proteins that recognize the mark (readers), such …

… and clinical samples of advanced PCa. Using validated in vitro and in vivo models [28, 29],
we demonstrate that the PRC1 member and epigenetic reader … predicts poor clinical outcome. …

… to new human stem-cell therapies, epigenetic regulators, which control the balance between
pluripotency and tumorigenicity, very likely have the potential to tip the scale. The best stem …

… Epigenetic players include enzymes that introduce (writers), recognize (readers), and remove
(erasers) epigenetic … This epigenetic code is interpreted by reader or effector proteins that …

… demethylases, remove these marks; and ‘readers’ are the effectors recruited to specifically …
interpret the epigenetic code and recruit ‘writers’ and ‘erasers’ 40, 71-74. Among the ‘readers’…

… such altered epigenetics. In this mini-review we introduce the concept of epigenetic drivers
of … in preclinical, or clinical development, and how they fit in the context of existing therapies. …

… UHRF1 provides new insights on the reading of the epigenetic code over a larger portion …
epigenetic marks. This paper reviews the principles how UHRF1 acts as an epigenetic reader …