… Polypharmacy can be justified in accordance with good clinical practice – if a state of well-being,
general health and improved body function are induced that will increase longevity. On …

… inconsistencies between clinical trials and clinical practice, … predictors of optimal dosages
for use in everyday practice. … they failed to respond to multiple drug therapy. The approach to …

… Inhaled therapy for PAH is an attractive concept that has been applied to clinical practice,
> 10 years ago, with the use of inhaled NO. Since intra-acinar pulmonary arteries are closely …

… in routine clinical practice is limited. Excepting a few examples of drug-metabolizing
enzymes, the contribution of genetic polymorphisms to individual differences in drug effects and …

… of therapeutic interventions vary from one patient to another. Therefore an individualized
therapeutic … physician in close cooperation with the patient and his caregiver in clinical practice. …

… We asked 4 specific questions: (1) How much interaction do authors of clinical practice
guidelines have with drug manufacturers and what is the nature of this interaction (ie, do the …

… Moreover, drug therapy itself will change as treatments using microsome drug
encapsulation and novel suspension media are introduced. Further on the clinical horizon is …

… In addition, these guidelines describe administration of therapies in clinical practice; … of
clinical trials, given that such clinical studies are designed to test innovative and novel therapies …

… therapy, including optimal dosing, the variable balance between benefits and risks when …
therapies are used alone or in combination with other antiplatelet drugs in different clinical …

… [1] An appreciation of the pharmacokinetics and its relationship with pharmacodynamics
is essential in understanding drug action and therefore optimizing drug therapy, both in …