Pharmacogenetics: the therapeutic drug monitoring of the future?

MHH Ensom, TKH Chang, P Patel - Clinical pharmacokinetics, 2001 - Springer
… the era of personalised drug therapy, we will … drug development and research, this review
will focus on current and future potential applications of pharmacogenetics in clinical practice. …

Integration and use of biomarkers in drug development, regulation and clinical practice: a US regulatory perspective

S Amur, FW Frueh, LJ Lesko, SM Huang - 2008 - Taylor & Francis
… Ultimately, we believe that testing for these biomarkers will greatly enhance drug therapy,
making drug products safer to use, while at the same time making efficacious outcomes more …

Compliance with osteoporosis drug therapy and risk of fracture

D Weycker, D Macarios, J Edelsberg, G Oster - Osteoporosis International, 2007 - Springer
… performed in clinical practice (as opposed to clinical trials of osteoporosis drug therapy), …
less likely to be recorded on medical claims than clinical vertebral fractures. In this case-control …

Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice

F Pisani, E Spina, G Oteri - Epilepsia, 1999 - Wiley Online Library
… of the commonly accepted therapeutic range, when available for that drug, or to those
usually observed in clinical practice in patients treated with therapeutic doses. This interesting …

[HTML][HTML] Sulfonylureas and their use in clinical practice

D Sola, L Rossi, GPC Schianca, P Maffioli… - Archives of medical …, 2015 - ncbi.nlm.nih.gov
… The European GUIDE study [59], for example, compared two sulfonylureas designed for
once-daily administration used under conditions of everyday clinical practice. Patients were …

The impact of clinical pharmacists on drug‐related problems and clinical outcomes

KK Viktil, HS Blix - Basic & clinical pharmacology & toxicology, 2008 - Wiley Online Library
… and interventions of clinical pharmacists in health care positively influence clinical practice.
… group, which had a clinical pharmacist actively adjusting the drug therapy, achieved a better …

Antiemetics: American Society of Clinical Oncology clinical practice guideline update

E Basch, AA Prestrud, PJ Hesketh, MG Kris… - Journal of Clinical …, 2011 - ascopubs.org
… and approved by the ASCO Clinical Practice Guidelines Committee and the Board of
Directors and underwent review and approval for publication in the Journal of Clinical Oncology. …

Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial

T Möttönen, P Hannonen, M Leirisalo-Repo, M Nissilä… - The Lancet, 1999 - thelancet.com
… The dose adjustments in both treatment regimens in our study were planned to mimic clinical
practice. Our primary aim was to compare the two treatment strategies. When we planned …

American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor–positive breast cancer

HJ Burstein, AA Prestrud, J Seidenfeld… - Journal of Clinical …, 2010 - ascopubs.org
… ASCO guidelines describe the use of procedures and therapies in clinical practice and cannot
be assumed to apply to the use of these interventions in the context of clinical trials. ASCO …

Evidence for therapeutic drug monitoring of targeted anticancer therapies

B Gao, S Yeap, A Clements, B Balakrishnar… - Journal of Clinical …, 2012 - ascopubs.org
… anticancer drug for which TDM is routinely used in clinical practice, and even then, drug
Nonadherence can contribute greatly to the variability observed in a drug's therapeutic effect, …