[HTML][HTML] PCSK9 inhibitors in clinical practice: delivering on the promise?
RM Stoekenbroek, ML Hartgers, R Rutte, DD de Wijer… - Atherosclerosis, 2018 - Elsevier
… PCSK9 inhibitors and placebo. PCSK9 inhibitors are increasingly used in clinical practice
and are incorporated in updates of clinical treatment guidelines based on these trial results […
and are incorporated in updates of clinical treatment guidelines based on these trial results […
[HTML][HTML] PCSK9 inhibitors: clinical relevance, molecular mechanisms, and safety in clinical practice
F Ferrari, R Stein, MT Motta… - Arquivos Brasileiros de …, 2019 - SciELO Brasil
… PCSK9 inhibitors (PCSK9i), a class of hypolipidemic monoclonal antibodies, is extremely
promising. PCSK9 inhibition … , with potential for very significant clinical repercussions, as every …
promising. PCSK9 inhibition … , with potential for very significant clinical repercussions, as every …
[HTML][HTML] The PCSK9 inhibitors: a novel therapeutic target enters clinical practice
NE Lepor, DJ Kereiakes - American Health & Drug Benefits, 2015 - ncbi.nlm.nih.gov
… By sequestering PCSK9, the PCSK9 inhibitors block the binding of PCSK9 protein to the
LDLR. … The PCSK9 inhibitors prolong the functional life span of, and amplify the effect of, each …
LDLR. … The PCSK9 inhibitors prolong the functional life span of, and amplify the effect of, each …
[HTML][HTML] PCSK9 inhibitors in clinical practice: novel directions and new experiences
LS Rallidis, I Skoumas, EN Liberopoulos… - Hellenic Journal of …, 2020 - Elsevier
… In randomized clinical trials, proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i)
effectively reduce low-density lipoprotein-cholesterol (LDL-C) with a favorable tolerability …
effectively reduce low-density lipoprotein-cholesterol (LDL-C) with a favorable tolerability …
PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations
Q Hao, B Aertgeerts, G Guyatt, GE Bekkering… - Bmj, 2022 - bmj.com
… Ezetimibe plus statins PCSK9 inhibitors plus statins or People adding a second lipid-lowering
drug We suggest adding ezetimibe first Strong All or nearly all informed people would …
drug We suggest adding ezetimibe first Strong All or nearly all informed people would …
PCSK9 inhibitors in clinical practice: expectations and reality
Ž Reiner - Atherosclerosis, 2018 - atherosclerosis-journal.com
… ] on PCSK9 inhibitors in clinical practice, patients were treated with PCSK9 inhibitors for a
relatively short period. Therefore, some possible adverse effects could not be seen. It has to …
relatively short period. Therefore, some possible adverse effects could not be seen. It has to …
[HTML][HTML] PCSK9 signaling pathways and their potential importance in clinical practice
M Wiciński, J Żak, B Malinowski, G Popek, G Grześk - EPMA Journal, 2017 - Springer
… On the other hand, PCSK9 inhibitors in recent experiments and clinical trials within phases
II and III showed little influence on HDL level and on the associated ApoA1. OSLER study …
II and III showed little influence on HDL level and on the associated ApoA1. OSLER study …
[HTML][HTML] Indications of PCSK9 inhibitors in clinical practice. Recommendations of the Spanish Society of Arteriosclerosis (SEA), 2019
JF Ascaso, F Civeira, C Guijarro, JL Miranda… - Clínica e Investigación …, 2019 - Elsevier
… document on the indications of PCSK9 inhibitors (PCSK9i) in clinical practice that was
published in 2016. This update is justified by the fact that the data from clinical trials carried out on …
published in 2016. This update is justified by the fact that the data from clinical trials carried out on …
Efficacy of PCSK9 inhibitors in the treatment of heterozygous familial hypercholesterolemia: A clinical practice experience
R Alonso, O Muñiz-Grijalvo, JL Díaz-Díaz… - Journal of Clinical …, 2021 - Elsevier
… -lowering therapy, who received PCSK9 inhibitors during the period 2016 to January 2020.
… clinical practice of patients with heterozygous FH with two monoclonal antibodies to PCSK9, …
… clinical practice of patients with heterozygous FH with two monoclonal antibodies to PCSK9, …
Application of PCSK9 inhibitors in practice: challenges and opportunities
TM Kaufman, PB Duell, JQ Purnell, C Wójcik… - Circulation …, 2017 - Am Heart Assoc
… of modern clinical medicine, efforts to implement PCSK9 inhibitors (… inhibition of PCSK9
in clinical practice through introduction of a new model of care delivery—the PCSK9i clinic…
in clinical practice through introduction of a new model of care delivery—the PCSK9i clinic…
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