The study aimed to identify genetic lesions associated with secondary acute myeloid
leukemia (sAML) in comparison with AML arising de novo (dnAML) and assess their impact
on patients' overall survival (OS). High‐resolution genotyping and loss of heterozygosity
mapping was performed on DNA samples from 86 sAML and 117 dnAML patients, using
Affymetrix Genome‐Wide Human SNP 6.0 arrays. Genes TP53, RUNX1, CBL, IDH1/2,
NRAS, NPM1, and FLT3 were analyzed for mutations in all patients. We identified 36 …

Abstract Background: Although R-CHOP has significantly improved outcome in diffuse large
B-cell lymphoma (DLBCL), 40% of patients still experience relapsed/refractory disease.
Further investigation into the genomic architecture of DLBCL is needed to determine the
biological correlates that underlie treatment failure. Recent studies using next-generation
sequencing strategies have described the landscape of recurrent mutations in DLBCL.
However, with the exception of TP53 and FOXO1, little is known about the clinical relevance …