… clinical trial do not capture clinical response adequately. Clinical thresholds are used to
judge whether a treatment has a clinically worthwhile effect or whether it is superior to another …

… biologic behavior: 1) the disease-free interval from primary tumor treatment to the appearance
of the clinical … brief disease-free interval from treatment of the primary cancer. Patients who …

… alone, as is done in most clinical settings, 5 they would likely … In a Swedish registry study,
decisions for biologic treatment … did not benefit from biologic treatment, another retrospective …

… patients matched for clinical characteristics to … treatment according to tumor, patient, and
treatment characteristics can be better defined. While the discussion about intensity thresholds …

… to anti-IL-5 treatment has been essential to see a clinical effect in subsequent clinical trials.
… been adjusted for exacerbations and blood eosinophil threshold. Note: No comparisons with …

… ), representing potential new users of biologic treatment in clinical practice, 20% were eligible
… This was largely driven by the different thresholds of eosinophils applied in the eligibility …

… threshold for clinicians … threshold in disease activity to switch. In addition, we explored
factors associated with continuing the biologic treatment regimen despite a suboptimal treatment …

… sclerosis, combines clinical data with biological samples and … We envisage that the setting
of the efficacy threshold should … treatments, patients' input on what would be clinically relevant …

… clinical rating scale thresholds. An intrinsic problem with KM survival analytic techniques is
that they measure the occurrence of a predefined event, eg, TEE, intervention, discontinuation…

… subjects to thresholds at the start but then changes treatments deterministically depending …
(if a subject reaches the threshold while on the initial treatment, then treatment is changed). In …