3D-bioprinted human tissue and the path toward clinical translation

JM Bliley, DJ Shiwarski, AW Feinberg - Science Translational Medicine, 2022 - science.org
… a tailored approach to tissue and organ engineering. In … human tissue and the proof-of-concept
applications that address long-standing challenges on the path toward clinical translation

Chasing the paradigm: clinical translation of 25 years of tissue engineering

T Hoffman, A Khademhosseini… - Tissue Engineering Part …, 2019 - liebertpub.com
… to the development and clinical translation of tissue engineering-inspired therapies, leading
… that facilitate tissue functional recovery. The foundation of tissue engineering involves the …

Tissue engineered constructs: perspectives on clinical translation

L Lu, HM Arbit, JL Herrick, SG Segovis, A Maran… - Annals of biomedical …, 2015 - Springer
… The field of tissue engineering and regenerative medicine is rapidly expanding, both in …
and in clinical translation.5 The development of tissue engineering scaffolds for clinical use has …

In vitro platforms for tissue engineering: implications for basic research and clinical translation

J Rouwkema, S Gibbs, MP Lutolf… - Journal of tissue …, 2011 - Wiley Online Library
Clinical translation of engineered tissues into regenerative medicine applications, and the …
, result in an increasing demand for human tissues engineered in vitro for implantation, in vitro …

Current challenges of bioprinted tissues toward clinical translation

D Ke, SV Murphy - Tissue Engineering Part B: Reviews, 2019 - liebertpub.com
… In summary, the use of bioprinting for biofabrication of human tissues for transplantation has
developed substantially over the past decade. Many studies have demonstrated promising …

Concise review: mind the gap: challenges in characterizing and quantifying cell-and tissue-based therapies for clinical translation

EA Rayment, DJ Williams - Stem Cells, 2010 - academic.oup.com
… before reaching clinical trials, especially in terms of whether in vitro efficacy tests will act as
successful surrogates for predicting in vivo human clinical response. Clinical endpoints have …

Human adipose-derived cells: an update on the transition to clinical translation

JM Gimble, BA Bunnell, F Guilak - Regenerative medicine, 2012 - Taylor & Francis
… The pace of discovery involving adipose-derived cells continues to accelerate at both the
preclinical and clinical translational levels. Adipose tissue is a source of freshly isolated, …

A perspective on the clinical translation of scaffolds for tissue engineering

MJ Webber, OF Khan, SA Sydlik, BC Tang… - Annals of biomedical …, 2015 - Springer
… Finally, we hope to provide insight into the clinical translation of technologies rooted in tissue
… on the road to translation, and the path forward for promising technologies in development. …

Advances in skin tissue bioengineering and the challenges of clinical translation

BL Dearman, ST Boyce, JE Greenwood - Frontiers in Surgery, 2021 - frontiersin.org
… In time, these technologies and advances in tissue engineering will at least reduce, and
possibly replace, the need for skin autografts and enable easier clinical translation of an …

Clinical translation in tissue engineering—the surgeon's view

CE Dlaska, G Andersson, M Brittberg… - Current Molecular …, 2015 - Springer
clinical translation needs relevant pre-clinical models, which provides similar anatomy and
comparable size translation, like in the clinical … surgeons to use it in the clinical human model. …