… clinical significance curve and risk-benefit contour to illustrate how the trade-off between
differences in trial … to estimate the additional clinical benefit of afatinib versus gefitinib 5 and the …

… As for the overall response rate, a comparison of the afatinib studies to the erlotinib and
gefitinib studies in first line in tumors harboring mutations in EGFR reveals very similar odds …

… Our purpose of this study is to investigate how afatinib is used in real-world practice, and
whether it leads to different clinical outcomes compared with gefitinib or erlotinib. …

… , although patients treated with afatinib had a slightly longer PFS… erlotinib, gefitinib, and
afatinib have equivalent efficacy. This meta-analysis included twelve phase III global clinical trials …

… , in contrast with the clinical pharmacokinetics of erlotinib.118, 119 … clinical implications.
As there is no solid evidence that gefitinib, erlotinib and afatinib differ much in efficacy, gefitinib …

… independent team from the trial sponsor with a validated computer system (clinical trial
supply system). This team was not involved in the rest of the trial. The randomisation sequence …

… clinical outcomes in prezviously untreated non-small cell lung cancer patients: results of an
online tumor registry of clinical trials… study of gefitinib versus carboplatin/paclitaxel in clinically …

… In this study, afatinib plus … , erlotinib/gefitinib and afatinib, after achieving an initial benefit
on each TKI. Randomized patients were clinically enriched based on their response to afatinib …

… The current study indicated that erlotinib, gefitinib, afatinib and icotinib … Erlotinib and afatinib
revealed potentially better efficacy but significant higher toxicities compared with gefitinib …

… 2014), embase (2006 to March 2014), and Cochrane Library (March 2014) databases were
searched for published practice guidelines, systematic reviews, and randomized clinical trials…