… However, to our knowledge no clinical trials on cognition are … Phase I clinical trial program
for their PDE4 inhibitor MEM 1414… inhibitors have been tested in clinical trials of aging and AD. …

… III clinical trials of any of the PDE inhibitors reviewed in this manuscript.In a 1998 meta-analysis
of four phase III, randomized, double-blind, placebo-controlled clinical trials ranging from …

… clinical trials, we have identified a particularly high number of clinical trials involving PDE
inhibitors… In total, we have identified 87 agents with PDE-inhibiting capacity, of which 85 interact …

… The data from the Phase 1 clinical trials with sildenafil in … In late 1993, the first clinical trial
examining the efficacy of … 5000 patients received sildenafil in clinical trials and in March 1998, …

… This compound has now completed its first clinical trial in the United States in adolescents
and adults, which compared 28 days of 0.2% with 0.5% versus vehicle ointment for mild-to-…

… The PDEs of potential relevance to lung diseases will be reviewed; particular emphasis will
be placed on PDE4 because inhibitors of PDE4 have reached the stage of clinical trials and …

… PDE4 inhibitors have been evaluated in clinical trials. … inhibitor demonstrated an improvement
in clinical scores and reduced T-cell number in the dermis in an open-label clinical trial (…

… In addition, the potential for use of oral phosphodiesterase inhibitors in conjunction with other
… the product more effective in clinical practice than it was as monotherapy in clinical trials. …

… several PDE inhibitors have been subjected to clinical trials for the … Most of these inhibitors
exhibited outstanding safety and … inhibitors have been subjected to phase II/III/IV clinical trials. …

… to therapeutically exploit the molecular diversity of the phosphodiesterases … number of drugs
are in clinical trials for asthma, and Viagra has become the first selective phosphodiesterase …