… are derived from group 2b β-lactamases (for example, TEM-1, TEM-2, and SHV-1); the e of
2be denotes that the β-lactamases have an extended spectrum. Group 2b enzymes hydrolyze …

… β-lactam rings of one or more members of the penicillins, cephalosporins, cephamycins,
carbapenems, and monobactams. Extended-spectrum β-lactamases (… by β-lactamase inhibitors …

… ESBLs are serine β-lactamases, belonging to Ambler molecular and structural classification
… hydrolyse expanded spectrum β-lactam antibiotics, and inhibition by β-lactamase inhibitors, …

… spread of extended-spectrum β-lactamase (ESBL) infections is highly correlated with the
shift in modern continuums of medical care, whereby patients with severe and complex medical …

… The metal ion(s) at the active site enables them to hydrolyze broad spectrum β-lactam
agents including carbapenems, but their ability can be inhibited by metal ion chelators, such as …

… of β-lactamases producing organisms. These enzymes extended spectrum βlactamases (…
has led to the development of enzymes having expanded substrate profile. To date, there …

… Production of β-lactamase is the most frequent β-lactam resistance mechanism in … of β-lactamases,
extended-spectrum β-lactamases (ESBLs) have played a leading role in the clinical …

Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae are a major global
public health concern. Presently, Escherichia coli with CTX-Ms are the most common species …

… We propose that from a clinical perspective we need a … an extended spectrum of β-lactam
hydrolysis. More important, the clinical consequences of transmission of these β-lactamases, …

… Using this method, several new TEM variants were identified within a set of clinical isolates.
The probes used in oligotyping tests for TEM βlactamases have been labeled either with a …