… (CLOCK) and brain and muscle aryl hydrocarbon receptor nuclear translocator‐like protein
1 (BMAL1) are master clock genes … as body temperature, heart rate and hormone secretion. …

… pattern of clock genes in a circadian series of pancreata collected from rats. In this way, they
provided support for the idea that a circadian clock was driving insulin secretion in a fashion …

… In addition, melatonin seems to influence clock gene expression and in some cases being
involved in endocrine disorders such as cortisol and insulin secretion. Pancreatic islets …

… With regard to the phase relationship between clock gene expression (reflected by the
Bmal1-luc profile) and insulin secretion, we found that the maximum level of secreted insulin …

… temporal variations of insulin secretion. … an insulin-secreting cell line (βTC-3). We observed
transcriptional daily variation of the TEF and DBP cell-clock genes and of islet-specific genes: …

… Animal models with molecular manipulation of clock genes and genetic studies in humans
… self-sustained clock, and recent studies have revealed an important role of clock genes in …

… clock controls insulin secretion 97 . … tissue clock gene expression rhythms in patients with
T2DM. One study described a reduced amplitude of the daily rhythm in leukocyte clock gene …

… processes) is an endogenous circadian clock comprised of a network of core clock genes
(BMAL1, … evidence that the postprandial increase of insulin secretion may be one of the most …

… had shorter insulin secretion circadian … with genetic modifications in clock genes have
revealed their key regulatory function in metabolism and glucose homeostasis. For instance, Clock …

… coordinates insulin secretion with the sleep/wake cycle, and Clock Δ19/Δ19 and pancreas-specific
Bmal1 − / − mutant mice show impaired glucose tolerance, reduced insulin secretion, …