… that clock genes are expressed in all six layers of the neocortex and the Purkinje and granular
cell layers of the cerebellar cortex of the mouse brain… neurons of the mouse neocortex and …

… , the clock genes are turned off and no new clock mRNA or protein is synthesised. After a
lag the existing proteins in the nucleus start to be broken down and the genes are released …

… brain areas outsides the SCN), clock genes might play a role in integrating the two processes
at a molecular level because, although clock genes are … This dual role of clock genes is the …

… mRNA and the PER1 and CLOCK protein levels in mouse brain. As the sleep-wake cycle
is under control of the circadian clock, the circadian master genes are expected to influence …

… clock gene proteins (CLOCK, BMAL1) in the mouse brain. Clock gene protein expression in
the brain … young (4 months) and older (16 months) mice sampled every 4 h over a 24-h cycle. …

… role for clock genes in sleep homeostasis. Studies in mice with targeted disruption for core
circadian clock genes … Clock-gene expression in brain areas outside the SCN, in particular the …

… Our results specifically show that SD decreases the binding of CLOCK, NPAS2, and BMAL1
to Dbp in the mouse brain. Since we previously observed that the SD-dependent decrease …

… the role of clock genes in … that mice deficient for one or more clock genes show an altered
response to sleep deprivation (SD) and on the observation that clock-gene expression in brain …

… on circadian clock gene product expression across numerous brain regions in the male
mouse to test the potential impact of such compounds on circadian timing. We report drug, brain …

… the mammalian clock genes, Clock and its partner, BMAL1, are expressed intensively in the
pineal, and in the olfactory bulb, hippocampus and cerebellum of the brain in rats. The gene …