… management of colorectal cancer (CRC) risk in IBD requires a fundamental understanding
of the evolutionary process underpinning tumorigenesis. In IBD, clonal evolution begins long …

… clonal evolution in mCRC and defined the relationship between PDXs and patient tumors. Our
reconstruction of the clonal evolution of … dissemination and xenograft clonal selection. This …

… Colorectal cancer (CRC) arises by a continuous process of genetic diversification and clonal
evolution. Multiple genes and pathways have a role in tumor initiation and progression. The …

… Cancer-clone evolution takes place within tissue ecosystem habitats. These habitats have
evolved … However, cancer-clone evolution probably passes a point of no return, possibly at the …

… to a complex interplay between clonal populations. Current evidence … between clonal
populations during neutral evolution gives … and diverse clonal populations in cancer progression. …

… focuses on intrapatient cancer heterogeneity and genetic clonal evolution in … clones, thereby
modulating clonal evolution. Tumor heterogeneity is strongly fueled by this clonal evolution, …

… Colon cancer is the third most common cancer worldwide. Most colorectal cancer … , 20–30%
of patients with colorectal cancer have a family history of colorectal cancer and 5% of these …

Simple Summary Half of all colorectal cancer (CRC) patients develop metastasis, despite
current management. The aim of this study was to help guide precision medicine in metastatic …

… Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and clonal
evolution. … ) to genotype colorectal tumors and track clonal evolution during treatment with …

… that metastatic potential is already acquired in founder clones, consistent with our neutral
evolution model. Mathematical modeling of the multiregion data indicated that metastatic …