… Ten out of the 12 treated cases underwent clonal evolution, in contrast to 1 of the … clonal
evolution displayed branched evolution, while the remaining 5 underwent linear clonal evolution …

… of drug-resistant traits. Within this review, we illuminate contemporary insights into the role of
clonal evolution in … , disease progression, and the formidable obstacle of therapy resistance. …

… from clonal evolution during anticancer drug treatment is directly related to drug resistance
… The selection of the optimal drug and drug administration procedure is not always based on …

… of genetic diversification and clonal evolution. Multiple genes … Current strategies for targeting
clonal evolution are described. … treatment plans to combat drug resistance may be devised. …

… clonal evolution over the disease course, with subsequent emergence of intratumor
heterogeneity (ITH). Evidence on gradual clonal … punctuated clonal evolution in short evolutionary …

… -clone evolution takes place within tissue ecosystem habitats. These habitats have evolved
… However, cancer-clone evolution probably passes a point of no return, possibly at the …

… by drug resistance may enhance the clonal spread of the most successful drug-resistant …
Drug resistance mutations and phenotypic drug resistance observed among Beijing sub-lineage …

… and cancer chemo-resistance.8-11 In this article we argue that clonal evolution of cancer cells
… validity of describing certain properties such as drug resistance as attributes of CSCs. We …

… Acquired drug resistance is related to clonal evolution and … de novo and acquired drug
resistance and should contain PIs, IMIDs, … and might prevent clonal evolution via sustained deep …

… and resistance. Finally, we will address the clinical implications of clonal evolution in disease
… stratification, evaluation of therapeutic response and management of therapy resistance. …