… of aberrant host DNA replication and recombination induced by HPV integration. We
conclude that HPV integration promotes intratumoral heterogeneity and clonal evolution. …

… However, how E6 and E7 could be expressed from the integrated viral … integrated HPV
DNA sites and expressed HPV RNAs in cervical cancer tissues and cell lines, we show that HPV …

… We found HPV integration has a positive effect on somatic mutation burden, but the …
evolution. In a conclusion, our study provides insights into the potential relationship between HPV …

… clonal evolution during high-risk HPV16-driven OPSCC development. We suggest that
HPV-… sensitive detection of viral integration, it is possible that HPV integration is able to occur …

… In addition, clonal evolution driven by HPV integration may result in the emergence of
subclones with distinct phenotypic characteristics, including differences in aggressiveness, …

… human papillomavirus (HPV). Here we report a striking association between HPV integration
and adjacent … active viral promoters, would be clonally selected. Deregulated expression of …

… This finding supports the data on HPV clonal evolution during HPV induced carcinogenesis
[40]. In the MJ-SC patient, we found the four same breakpoints in the primary tumour and …

… by HPV, recent findings on the process of viral integration into the host genome, new methods
to detect HPV integration, … viral integrations due to a possible clonal selectivity. Therefore, …

… Understanding clonal evolution related to HPV integration is of great significance in revealing
the mechanism of cervical tumor progression and metastasis which could then lead to the …

… and tumours was undertaken using antisense oligonucleotide probes for the HPV-16 E6-E7
region (clone 056-26; 65–875 bp) and the E2–E5–L2 region (clone 056-14; 3697–4761 bp). …