New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin
H Barth, K Aktories - European journal of cell biology, 2011 - Elsevier
… The C2 toxin from Clostridium botulinum represents the … cells resulting in depolymerization
of actin filaments and cell rounding. … HeLa cells and the key inducers of mitotic entry, p34 cdc2 …
of actin filaments and cell rounding. … HeLa cells and the key inducers of mitotic entry, p34 cdc2 …
Cellular Uptake of the Clostridium perfringens Binary Iota-Toxin
D Blöcker, J Behlke, K Aktories, H Barth - Infection and immunity, 2001 - Am Soc Microbiol
… In contrast to C2 toxin of Clostridium botulinum, iota a ADP-ribosylates both muscle and …
-toxin, iota b, recognizes an unknown cell surface receptor and mediates cell entry of iota a (9). …
-toxin, iota b, recognizes an unknown cell surface receptor and mediates cell entry of iota a (9). …
Clostridium botulinum neurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and …
… Clostridium botulinum neurotoxin A (BTX) is a polypeptide produced by the bacterium Clostridium
botulinum… levels in the DBTRG glioblastoma and SH-SY5Y neuroblastoma tumor cells. …
botulinum… levels in the DBTRG glioblastoma and SH-SY5Y neuroblastoma tumor cells. …
Clostridium botulinum neurotoxin A inhibits DBTRG glioblastoma cell proliferation and TRPV1 channel signaling pathways
Y Akyuva - Journal of Cellular Neuroscience and Oxidative Stress, 2020 - dergipark.org.tr
… Clostridium botulinum neurotoxin A (BotxA) acted antioxidant action in several cells and
its … Hence, treatment of BotxA may modulate glioblastoma cell proliferation and death via …
its … Hence, treatment of BotxA may modulate glioblastoma cell proliferation and death via …
Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol
BJ Pavlik, EJ Hruska, KE Van Cott, PH Blum - Scientific reports, 2016 - nature.com
… Clostridium botulinum C2 toxin was then delivered to human glioblastoma A172 and
synchronized HeLa cells. In … C1 H C entry was shown to be GT1b-dependent in N2A cells that …
synchronized HeLa cells. In … C1 H C entry was shown to be GT1b-dependent in N2A cells that …
Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro
N Kobayashi, K Abe, S Akagi, M Kitamura… - Frontiers in …, 2022 - frontiersin.org
… In the present study, we focused on the cellular effects of MVs derived from C. … To identify
the entry route of MVs in RAW264.7 cells, these cells were treated with FITC-MVs in the …
the entry route of MVs in RAW264.7 cells, these cells were treated with FITC-MVs in the …
Role of Host Cell Chaperones in Cellular Uptake of Clostridium Botulinum C2 Toxin
E Kaiser, H Barth - The Open Toxinology Journal, 2010 - benthamopen.com
… Abstract: The binary C2 toxin from Clostridium botulinum … C2I into the cytosol of eukaryotic
host cells. In the cytosol, C2I mono-… Rapid entry of nicked diphtheria toxin into cells at low Ph: …
host cells. In the cytosol, C2I mono-… Rapid entry of nicked diphtheria toxin into cells at low Ph: …
Clostridium botulinum C2 toxin: binding studies with fluorescence-activated cytometry
BG Stiles, D Blöcker, ML Hale, MA Guetthoff, H Barth - Toxicon, 2002 - Elsevier
… Clostridium botulinum C2 enterotoxin consists of two unlinked proteins designated as C2II,
which recognizes a cell… on the cell-surface yet not gain entry into a target cell. Studies have …
which recognizes a cell… on the cell-surface yet not gain entry into a target cell. Studies have …
Uptake of botulinum neurotoxin in the intestine
Y Fujinaga, Y Sugawara, T Matsumura - Botulinum Neurotoxins, 2013 - Springer
… -forming bacteria Clostridium botulinum, C. butyricum, and … , but type C HA lacks this activity
with respect to human cell lines … , type C HA disrupts the epithelial barrier in cultured cells …
with respect to human cell lines … , type C HA disrupts the epithelial barrier in cultured cells …
Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B
G Masuyer, M Beard, VA Cadd, JA Chaddock… - Journal of Structural …, 2011 - Elsevier
… 1 and -2 when added to the cells at high concentration. These activities of the LHn/B fragment
demonstrate the utility of engineered botulinum neurotoxin fragments as analytical tools to …
demonstrate the utility of engineered botulinum neurotoxin fragments as analytical tools to …