… , genetic studies clearly demonstrated that coagulase and clumping factor are distinct (McDevitt
et ai, … In this paper we report the isolation of clumping factordeficient mutants of S. aureus …

… Recently, the gene encoding the fibrinogen-binding protein called clumping factor (ClfA),
was cloned and sequenced from S. aureus strain Newman [IS]. An 896-amino acid protein (mo…

… Staphylococcus aureus is a major cause of nosocomial and community-acquired … factors
that promote avoidance of phagocytosis by polymorphonuclear leucocytes. Clumping factor A (…

… role of staphylococcal coagulase and clumping factor was … and clumping factor-producing
parent strain Staphylococcus … of clumping factor, we also tested in parallel a clumping factor-…

… colonization assay to investigate the involvement of a bacterial surface protein called clumping
factor B (ClfB) in the survival of S. aureus in the human nose. ClfB binds to cytokeratin 10, …

… The surface-located fibrinogen-binding protein (clumping factor; ClfA) of Staphylococcus
aureus has an unusual dipeptide repeat linking the ligand binding domain to the wall-anchored …

… aureus, we have now characterized extensively the mutation within strain PS12. Our results
indicate that staphylococcal clumping factor A (ClfA) (21), recognized initially for its role in …

… In this paper we report our efforts to dissect the functions of the clumping factor protein and
to localize within it the fibrinogen-binding domain(s}. The strategy employed was to amplify …

… Clumping factor B (ClfB) from Staphylococcus aureus is a bifunctional protein that binds
to human cytokeratin 10 (K10) and fibrinogen (Fg). ClfB has been implicated in S. aureus …

… The staphylococcal clumping factor A (clfA) gene was cloned into pOri23 … clump in the
presence of plasma. ClfA-positive lactococci had clumping titers (titer of 4,112) similar to those of S…