Translation of the Philadelphia chromosome into therapy for CML
BJ Druker - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
… Complete response (CR) and partial response (PR) for cytogenetic responses include patients
with Ph chromosome–positive metaphases of less than or equal to 35%. Illustration by AY …
with Ph chromosome–positive metaphases of less than or equal to 35%. Illustration by AY …
The Philadelphia chromosome in leukemogenesis
ZJ Kang, YF Liu, LZ Xu, ZJ Long, D Huang… - Chinese journal of …, 2016 - Springer
… All CML-BC patients co-express both transcripts [44]. … Ph-positive CML patients, which
found that 90.4% of patients expressed p210 BCR-ABL1 , and approximately 7% of patients with …
found that 90.4% of patients expressed p210 BCR-ABL1 , and approximately 7% of patients with …
Applying the discovery of the Philadelphia chromosome
DW Sherbenou, BJ Druker - The Journal of clinical …, 2007 - Am Soc Clin Investig
… — blast crisis CML and Ph chromosome–positive … patients with blast crisis CML of myeloid
phenotype and in 70% (n = 20) of patients with lymphoid blast crisis CML or Ph chromosome–…
phenotype and in 70% (n = 20) of patients with lymphoid blast crisis CML or Ph chromosome–…
Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias
NP Shah, CL Sawyers - Oncogene, 2003 - nature.com
… of 11 patients with relapsing advanced phase CML, three of … CML, and two of two cases
of Philadelphia chromosome-… 10 patients with persistence of the Philadelphia chromosome …
of Philadelphia chromosome-… 10 patients with persistence of the Philadelphia chromosome …
The distribution of the Philadelphia chromosome in patients with chronic myelogenous leukemia
J Whang, E FREI III, JH Tjio, PP Carbone, G Brecher - Blood, 1963 - ashpublications.org
… The presence of Ph 1 chromosomes was also studied in cultures of peripheral blood. In
six patients in relapse, 40 per cent of metaphases contained the Ph 1 chromosome, and the …
six patients in relapse, 40 per cent of metaphases contained the Ph 1 chromosome, and the …
Clonal chromosomal abnormalities appearing in Philadelphia chromosome–negative metaphases during CML treatment
GC Issa, HM Kantarjian, GN Gonzalez… - Blood, The Journal …, 2017 - ashpublications.org
… chromosomal abnormalities in Philadelphia chromosome-negative (CCA/Ph − ) metaphases
emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are treated …
emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are treated …
Discovery of the Philadelphia chromosome: a personal perspective
PC Nowell - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
… chromosome. As technology advanced over subsequent decades, the translocation resulting
in the Philadelphia chromosome has been identified, its role in the development of CML …
in the Philadelphia chromosome has been identified, its role in the development of CML …
BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review
X An, AK Tiwari, Y Sun, PR Ding, CR Ashby Jr… - Leukemia research, 2010 - Elsevier
… Identifying key components involved in the CML pathogenesis … the current treatment of Ph+
CML patients with the TKIs and … failure in Philadelphia chromosome-positive CML patients. …
CML patients with the TKIs and … failure in Philadelphia chromosome-positive CML patients. …
Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia
CR Bartram, A de Klein, A Hagemeijer, T van Agthoven… - Nature, 1983 - nature.com
… of CML, we have now studied two CML patients with … to counts for chromosome 9 and the
Philadelphia chromosome. If … control and the Ph'-positive CML. An excess of grains over the Y …
Philadelphia chromosome. If … control and the Ph'-positive CML. An excess of grains over the Y …
Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome
CB Lozzio, BB Lozzio - 1975 - ashpublications.org
… from a patient with chronic myelogenous leukemia (CML) is … characteristics: (1) CML cells
started to proliferate actively since … examined show the Philadelphia (Ph1) chromosome and a …
started to proliferate actively since … examined show the Philadelphia (Ph1) chromosome and a …
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