… lung cancer care. In this article, we review the management and recent advances in the
treatment of lung cancer with spread to the CNS… Discordant CNS and extra CNS responses were …

… Remarkably, in this population, which was probably enriched for patients with activating
EGFR mutations (Asian ethnicity, mostly never-smokers, adenocarcinomas), the CNS response …

… CNS DCR (CDCR) was defined as the percentage of patients who had a best overall CNS
response … first observation of a CNS response until the first observation of CNS progression or …

… Prophylactic cranial irradiation is indicated following complete response to induction
therapy in small cell lung cancer: results of a multicentre randomised trial. United Kingdom …

… chemotherapy for BM, with intracranial response rates (RR) comparable to systemic RR,
warranting further research on the role of chemotherapy in CNS disease from NSCLC (7-12). …

… cell lung cancer (NSCLC) is characterized by a high prevalence of central nervous system
(CNS… Although CNS responses are well documented with ceritinib, these differences, together …

… was CNS objective response rate (ORR). … CNS tumor shrinkage. Additional analyses
included the effect of prior radiotherapy on CNS response and a competing risk analysis of CNS …

… CNS response lasting in the range of 9–12 months only (Table 1). In addition, while there
is limited data on toxicities from combined approaches of SRS and TKIs, there is the potential …

… central nervous system (CNS) and elicit responses in patients with brain metastases (BM)
from non–small cell lung cancer (… impact on the development and control of CNS metastases. …

… The overall CNS response rate was 10% (1/10); 2 others achieved CNS stability. Median
overall survival was 1.7 months (range 0.6 – 7.0). There was no clear correlation between …