… activity in the CNS in phase I and II studies. To further evaluate the efficacy of alectinib in
the CNS, we pooled efficacy and safety data for patients with CNS disease from the phase II …

… patients who received early CS and those patients who received concomitant CS. Of the
analyzed factors, only ECOG was associated with complete response … complete response in our …

… To achieve a longer response duration, a maintenance therapy may be required that is
tolerated by these older and heavily pretreated patients. First anecdotal reports on temozolomide …

… response to initial standard high‐dose methotrexate‐based chemotherapy (HD‐MTX), half
of patients … We sought to identify pretreatment biological parameters that predict or improve …

… type I serology, lymphoma outside the CNS at the pretreatment systemic work-up (including …
response achieved in each patient. The median duration of response of the 21 patients with …

… but involves the risk of additional CNS toxicity, especially in older patients [5]. … response
and CR rate as well as the pretreatment characteristics were compared between both patient …

… response rate for CNS lesions based on CT scans was 33% with three CR (10%) and seven
PR (23%). The CNS metastases stabilised in 8 patients (27… and severely pretreated patients. …

… A complete response was defined as more than a 95% reduction in tumor size compared
with pretreatment CT scans, a partial response as a reduction of more than 25% and less than …

… In the current protocol, 44 of 52 patients had stable or better responses, and 32 of these …
only for patients who were found to have positive CSF on pretreatment screening evaluation. …

… Importantly, these responses were achieved in a population of heavily pretreated patients. …
Penetration of N-(phosphonacetyl)-L-aspartate into human central nervous system and …