Codon usage bias and environmental adaptation in microbial organisms

D Arella, M Dilucca, A Giansanti - Molecular Genetics and Genomics, 2021 - Springer
… For codon usage more infrequent than the average codon usage, the RSCU is less than one,
and for more frequent usage than the average for the amino acid, the RSCU is greater than …

Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages

Z Yang, R Nielsen - Molecular biology and evolution, 2002 - academic.oup.com
… of codon usage, Fequal and Fcodon, with the results shown in table 6 . Although codon usage
is … models, and the results of the LRT are robust to assumptions about codon usage bias. …

Measuring and detecting molecular adaptation in codon usage against nonsense errors during protein translation

MA Gilchrist, P Shah, R Zaretzki - Genetics, 2009 - academic.oup.com
… We then use these results to define the nonsense error adaptation index (NAI) of the allele or
a … of adaptation to reduce the cost of nonsense errors and increasing adaptation with codon

A major controversy in codon-anticodon adaptation resolved by a new codon usage index

X Xia - Genetics, 2015 - academic.oup.com
… , (2) codon usage and tRNA anticodons coevolve to adapt to … a high degree of codon-anticodon
adaptation. These studies … mutation and selection on codon usage (Chithambaram et al…

The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications

PM Sharp, WH Li - Nucleic acids research, 1987 - academic.oup.com
… Our discussion of the use of the Codon Adaptation Index has focussed on unicellular
organisms because the determinants of codon usage in multicellular organisms are not well …

Codon usage bias

ST Parvathy, V Udayasuriyan, V Bhadana - Molecular biology reports, 2022 - Springer
… Knowledge of codon usage of plants will therefore help in understanding the molecular
mechanisms of environmental adaptation and biological diversity of each plant species [9]. The …

Statistical methods for detecting molecular adaptation

Z Yang, JP Bielawski - Trends in ecology & evolution, 2000 - cell.com
… Numerous cases of molecular adaptation are being identified in various systems from
viruses to humans. Although previous analyses averaging rates over sites and time have little …

Viral adaptation to host: a proteome‐based analysis of codon usage and amino acid preferences

I Bahir, M Fromer, Y Prat, M Linial - Molecular systems biology, 2009 - embopress.org
… be considered as a manifestation of some molecular adaptation mechanisms. We develop
a … of a molecular adaptation of viruses toward their hosts, we focus on the codon usage and …

No evidence for tissue-specific adaptation of synonymous codon usage in humans

M Sémon, JR Lobry, L Duret - Molecular biology and evolution, 2006 - academic.oup.com
codon usage of 2,126 human tissue-specific genes expressed in 18 different tissues. We
confirm that synonymous codon usage … variability of synonymous codon usage between tissues …

Synonymous but not silent: the codon usage code for gene expression and protein folding

Y Liu, Q Yang, F Zhao - Annual review of biochemistry, 2021 - annualreviews.org
Codon usage influences translation elongation speed and regulates … Adaptation of codon
usage to tRNA expression determines the proteome landscape. In addition, codon usage