Cognitive impairment following high fat diet consumption is associated with brain inflammation

PJ Pistell, CD Morrison, S Gupta, AG Knight… - Journal of …, 2010 - Elsevier
… This report shows a clear association between cognitive impairment and increased brain
inflammation. While this association cannot indicate causality per se, there are ample data to …

[HTML][HTML] High fat diet induces brain insulin resistance and cognitive impairment in mice

V Kothari, Y Luo, T Tornabene, AM O'Neill… - … et Biophysica Acta (BBA …, 2017 - Elsevier
cognitive functions. Six week old, male C57BL/6NHsd mice were randomly assigned a high
fat diet (40% energy from fat… normal chow diet (12% energy from fat) for 14 weeks. Metabolic …

High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

CD Morrison, PJ Pistell, DK Ingram… - Journal of …, 2010 - Wiley Online Library
… ‘western diet’ (41% fat), very high fat lard diet (60% fat), or corresponding control diets for 16
high fat lard diet increased age-related oxidative damage (protein carbonyls) and impaired

Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's disease

SK Sah, C Lee, JH Jang, GH Park - Biochemical and biophysical research …, 2017 - Elsevier
… recent study using 3xTg-AD mice model established the fact, backing our findings, that dietary
fat induces cognitive impairment without any involvement of either Aβ or tau pathology [1]. …

Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms

LR Freeman, V Haley-Zitlin… - Nutritional …, 2014 - Taylor & Francis
… mechanisms by which a high fat diet and/or obesity can alter the brain and cognition. It is well
… Within this review, we primarily refer to ‘cognitive decline’ or ‘cognitive impairment’ in order …

Cognitive impairment in rats fed high-fat diets: a specific effect of saturated fatty-acid intake.

CE Greenwood, G Winocur - Behavioral neuroscience, 1996 - psycnet.apa.org
… diets over a 3-month period were found to be severely impaired on several tests of learning
… diets high in saturated or polyunsaturated fat produced widespread cognitive impairment that …

Highfat‐diet intake enhances cerebral amyloid angiopathy and cognitive impairment in a mouse model of Alzheimer's disease, independently of metabolic disorders

B Lin, Y Hasegawa, K Takane, N Koibuchi… - Journal of the …, 2016 - Am Heart Assoc
… of AD and cognitive impairment. To elucidate the potential mechanism underlying
cognitive impairment by highfat diet in 5XFAD, we examined the effect of highfat diet on …

[HTML][HTML] The health effect of probiotics on high-fat diet-induced cognitive impairment, depression and anxiety: A cross-species systematic review

J Lof, K Smits, V Melotte, LE Kuil - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
… obesity- or high-fat diet (HFD)-related cognitive impairment, … on HFD-induced cognitive
impairment and anxiety. However, … absence of HFD-induced impairment. Future studies should …

High-fat diets, insulin resistance and declining cognitive function

CE Greenwood, G Winocur - Neurobiology of aging, 2005 - Elsevier
… and DM2, leading to the hypothesis that at least one mechanism linking high fat, high
saturated fat, intake to cognitive impairment is through the development of insulin resistance. …

[HTML][HTML] Short-term high-fat diet (HFD) induced anxiety-like behaviors and cognitive impairment are improved with treatment by glyburide

SJ Gainey, KA Kwakwa, JK Bray, MM Pillote… - Frontiers in behavioral …, 2016 - frontiersin.org
Obesity-associated comorbidities such as cognitive impairment and anxiety are increasing …
with a high-fat diet (HFD) from weaning for 1, 3 or 6 weeks. When compared to low-fat diet (…